Search for dissertations about: "ES cell"

Showing result 1 - 5 of 59 swedish dissertations containing the words ES cell.

2. 1. Identification of stem cell factors - Novel protein-protein interactions and their functions

   Author : Helena Johansson; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; embryonic stem cells; Tpt1; Npm1; Ncl; Oct4; Sox2; Nanog; SAF-A; cell proliferation; transcriptional regulation;

   Abstract : Embryonic stem (ES) cells provide an unlimited source of cells potentially useful for regenerative medicine, however, prior to clinical implementation, additional basic research is needed. This thesis is focused upon different molecular aspects regarding ES cells, primarily by finding novel stem cell protein-protein interactions and their functions. READ MORE

4. 2. Molecular mechanisms of embryonic stem cell pluripotency: transcription, telomere maintenance and proliferation

   Author : Dzeneta Vizlin-Hodzic; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; embryonic stem cells; Oct4; SAF-A; Brg1; Tpt1; Npm1; transcriptional regulation; cell proliferation; shelterin;

   Abstract : Somatic cell nuclear transfer and generation of induced pluripotent stem cells provide potential routes towards generation of patient specific embryonic stem (ES) cells. These procedures require induction of Oct4 gene expression, high telomerase activity and specific cell proliferation, characteristics shared with cancer stem cells. READ MORE

5. 3. Novel Regulators of Brain Tumor Development : – From neural stem cell differentiation to in vivo models

   Author : Anqi Xiong; Karin Forsberg Nilsson; Joanna Phillips; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioma; medulloblastoma; neural stem cell; heparanase; NRBP2; dog models; susceptibility;

   Abstract : Malignant brain tumors are diseases with poor prognosis and/or severe long-term side effects of treatment. This thesis aimed to discover novel regulators in brain tumor development, based on studying neural stem cell and progenitor cell (NSPC) differentiation and using animal models to introduce new insights to mechanisms of human brain tumors. READ MORE

6. 4. Heparan Sulfate Regulation of Fibroblast Growth Factor (FGF) Receptor-1 Signal Transduction

   Author : Lars Lundin; Lena Claesson-Welsh; Marco Presta; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; FGF; FGFR; dimerisation; signal transduction; heparan sulfate; proteoglycan; heparin; VEGF; embryonal stem cell; endothelial cell; differentiation; Patologi; Pathology; Patologi;

   Abstract : Fibroblast growth factors (FGFs) constitute a family (currently FGF-1 to FGF-23) of polypeptides that are essential in embryonal development and adult physiology, in animals from nematodes to humans. FGFs bind to four receptor tyrosine kinases, denoted FGFR-1 to FGFR-4. READ MORE

7. 5. The role of Shb in ES cell differentiation, angiogenesis and tumor growth

   Author : Nina Funa; Michael Welsh; Leif Jansson; Lars Holmgren; Uppsala universitet; []
   Keywords : Cell biology; Shb; tyrosine kinase signaling; ES; endoderm; mesoderm; apoptosis; microvasculature; tumor growth; Cellbiologi;

   Abstract : Shb is a ubiquitously expressed adaptor protein with the ability to bind several tyrosine kinase receptors and intracellular signaling proteins. Previous studies have implied a wide spectrum of Shb-mediated cellular responses, which motivated me to further investigate the role of Shb in differentiation and angiogenesis. READ MORE