Search for dissertations about: "ESI-MS MS"
Showing result 1 - 5 of 83 swedish dissertations containing the words ESI-MS MS.
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1. Interfacing HPLC with MALDI- and ESI-MS for Automated High Sensitivity Analysis of Proteins and Peptides
Abstract : The research described in this thesis has an interdisciplinary approach dealing with chemical, biological, and technical issues. One objective was to interface miniaturized liquid chromatography (LC) to mass spectrometry, i.e. MALDI-TOF MS and ESI-MS, in an unattended mode for high sensitivity determination of proteins and peptides. READ MORE
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2. Novel clean-up, concentration and laser desorption/ionization strategies for mass spectrometry
Abstract : Despite valuable advantages of mass spectrometry (MS) techniques they still have drawbacks that need to be overcome, notably their sensitivity to various kinds of interfering substances and associated difficulties involved in detecting signals from analytes present in trace quantities. Thus, high quality analytical data could be acquired by improving sample pre-treatment techniques and/or ionization methods to increase ionization yields and/or avoid the generation of unwanted ions. READ MORE
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3. Characterisation of the Substituent Distribution in Starch and Cellulose Derivatives
Abstract : Starch and cellulose can be chemically modified to produce derivatives with specific properties. Knowledge of correlations between the modification reaction, substituent distribution and properties is important in order to design modification processes so as to produce derivatives with the desired properties. READ MORE
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4. Methods for structural studies of an antibody, screening metabolites in rat urine and analysis of spent cell cultivation media using LC/ESI-MS and chemometrics
Abstract : This thesis describes bioanalytical methods for generating fingerprints of biological systems for extracting relevant information with (protein) drugs in focus. Similarities and differences between samples can reveal the hidden relevant information, which can be used to optimize the production and facilitate the quality control of such protein drugs during their development and manufacture. READ MORE
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5. Tuning the polylactide hydrolysis rate without introducing new migrants
Abstract : The possibility to control and tune the hydrolytic degradation rate of polylactide without introducing any new degradation products was investigated by subjecting polylactide with cyclic or linear oligolactic acid additives, and a stereocomplex between the L- and D-enantiomers of polylactide to hydrolytic degradation at 37 and 60 °C for up to 39 weeks. The degradation was monitored by measuring mass loss, molar mass changes, water uptake, changes of surface structure, crystallinity and thermal properties. READ MORE
