Search for dissertations about: "ET-1"

Showing result 1 - 5 of 55 swedish dissertations containing the word ET-1.

  2. 1. Novel Interventions in Cardiac Arrest : Targeted Temperature Management, Methylene Blue, S-PBN, Amiodarone, Milrinone and Esmolol,  Endothelin and Nitric Oxide In Porcine Resuscitation Models

    Author : Frank Zoerner; Fredrik Lennmyr; Cécile Martijn; Lars Wiklund; Sven Erik Gisvold; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; restoration of spontaneous circulation; ROSC; cardiopulmonary resuscitation; CPR; cardiac arrest; methylene blue; MB; S-PBN; mild therapeutic hypothermia; MTH; targeted temperature management; TTM; endothelin; ET-1; ECE-1; ETAR; ETBR; nitric oxide; NO; nitric oxide synthase; NOS; eNOS; iNOS; nNOS; porcine; amiodarone; hypovolemia; milrinone; vasopressin; esmolol; epinephrine; Anaesthesiology and Intensive Care; Anestesiologi och intensivvård; Medical Cell Biology; Medicinsk cellbiologi; Kardiologi; Cardiology;

    Abstract : It is a major clinical problem that survival rates after out-of-hospital cardiac arrest have not markedly improved during the last decades, despite extensive research and the introduction of new interventions. However, recent studies have demonstrated promising treatments such as targeted temperature management (TTM) and methylene blue (MB). READ MORE

  4. 2. Cardiovascular and metabolic effects of endothelins in man : an experimental and clinical study

    Author : Astrid Ottosson-Seeberger; Karolinska Institutet; Karolinska Institutet; []
    Keywords : endothelin-1; big ET-1; C-terminal big ET-1 22-3 8 fragment; hemodynamic; blood flow; fractional extraction; conversion; plasma half-life; end-stage renal failure; ischemic heart disease; hemodialysis; high-flux membrane; glucose uptake; insulin sensitivity;

    Abstract : Increased plasma concentrations of endothelin-1 (ET-1) and of its propeptide big endothelin-1 have been reported in diseases associated with endothelial dysfunction, cardiovascular remodelling and insulin resistance. In this thesis, we studied the hemodynamic effects of big ET-1 in healthy humans focusing on the mechanisms of the effects (study I-IV). READ MORE

  5. 3. Unusual vascular responses in the umbilical artery, mediated by endothelin-like receptors

    Author : Maria Laursen; Urogynekologi och reproduktionsfarmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reproduction; sexuality; Obstetrik; gynekologi; andrologi; sexualitet; andrology; gynaecology; Obstetrics; Medicin människa och djur ; Medicine human and vertebrates ; unusual vascular responses; endothelin-like receptors; human umbilical artery; reproduktion;

    Abstract : In this present study the population of endothelin-like receptors in the human umbilical artery was examined in vitro in different parts of the umbilical cord. Immunohistochemistry revealed ETB receptors in the endothelium and an uneven distribution of ETA receptors in the smooth muscle of the arterial wall, when comparing different parts of the umbilical artery. READ MORE

  6. 4. The importance of endothelin-1 for vascular function in patients with atherosclerosis and healthy controls

    Author : Felix Böhm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Acetylcholine; atherosclerosis; blood flow; circulation; coronary disease; endothelin; endothelium; kidney; liver; nitric oxide; patients; receptors; vasoconstriction.;

    Abstract : Background: Atherosclerosis is associated with endothelial dysfunction, which is an early sign with prognostic implications in patients with coronary artery disease. Atherosclerosis is also associated with enhanced expression of the vasoconstrictor peptide endothelin-1 (ET-1). READ MORE

  7. 5. Endothelin in the pulmonary circulation with special reference to hypoxic pulmonary vasoconstriction

    Author : Peter Holm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : bosentan; BMS-182874; ; BQ-123; BQ-788; endothelin; endothelium; hypoxia; hypoxic pulmonary vasoconstriction; pulmonary hypertension; receptor antagonism; TBC 11251.;

    Abstract : A number of substances originating from the pulmonary endothelium have recently been found to be involved in the regulation of pulmonary vascular tone. Accumulating evidence suggests that endothelial dysfunction contributes to pulmonary hypertension, an important clinical problem often associated with hypoxemia. READ MORE