Search for dissertations about: "ETA receptor"

Showing result 11 - 15 of 31 swedish dissertations containing the words ETA receptor.

  2. 11. The importance of nitric oxide bioavailability and endothelial mechanisms for cardioprotection by pharmacological intervention during myocardial ischaemia and reperfusion

    Author : Andrey Gourine; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ATP sensitive K channels; endothelin-1; clevidipine; ETA receptor antagonist; glibenclamide; 5-hydroxydecanoic acid; infarct size; ischaemia; myeloperoxidase; nitric oxide; nitric oxide synthase; pig; preconditioning; rat; reperfusion.;

    Abstract : Myocardial ischaemia initiates complex severe cellular changes and, after a critical time period, myocardial cell death. Despite that restitution of coronary blood flow is an absolute pre-requisite for tissue survival, myocardial reperfusion per se will also increase irreversible damage in the jeopardised myocardium. READ MORE

  4. 12. Endothelin in the pulmonary circulation with special reference to hypoxic pulmonary vasoconstriction

    Author : Peter Holm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : bosentan; BMS-182874; ; BQ-123; BQ-788; endothelin; endothelium; hypoxia; hypoxic pulmonary vasoconstriction; pulmonary hypertension; receptor antagonism; TBC 11251.;

    Abstract : A number of substances originating from the pulmonary endothelium have recently been found to be involved in the regulation of pulmonary vascular tone. Accumulating evidence suggests that endothelial dysfunction contributes to pulmonary hypertension, an important clinical problem often associated with hypoxemia. READ MORE

  5. 13. The role of endothelin during myocardial ischaemia and reperfusion : pathophysiological mechanisms and interactions with nitric oxide

    Author : Adrian T Gonon; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ischaemia; reperfusion injury; myocardium; infarct size; endothelium; endothelin; endothelin receptor; nitric oxide; nitric oxide synthase; polymorphonuclear leukocytes; myeloperoxidase; pig; rat;

    Abstract : Acute myocardial infarction followed by reperfusion results in accelerated necrosis of irreversibly injured myocytes as well as induction of lethal injury to reversibly injured cells. Polymorphonuclear leukocytes (PMNs) are major participants in the reperfusion-initiated inflammation. READ MORE

  6. 14. Endothelin and angiotensin II receptors in human coronary arteries and bypass grafts - Alterations in cardiovascular disease

    Author : Angelica Wackenfors; Lunds universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kardiovaskulära systemet; Cardiovascular system; vasoconstriction; receptors; cardiovascular disease; human; coronary arteries;

    Abstract : Angiotensin II (Ang II) and endothelin-1 (ET-1) induce strong vasoconstriction via activation of receptors on vascular smooth muscle cells. In this thesis, the contractile Ang II and endothelin receptors were examined in endothelium-denuded human coronary arteries and in bypass grafts (the left internal mammary artery and the saphenous vein), with focus on receptor alterations in cardiovascular disease. READ MORE

  7. 15. The importance of endothelin-1 for vascular function in patients with atherosclerosis and healthy controls

    Author : Felix Böhm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Acetylcholine; atherosclerosis; blood flow; circulation; coronary disease; endothelin; endothelium; kidney; liver; nitric oxide; patients; receptors; vasoconstriction.;

    Abstract : Background: Atherosclerosis is associated with endothelial dysfunction, which is an early sign with prognostic implications in patients with coronary artery disease. Atherosclerosis is also associated with enhanced expression of the vasoconstrictor peptide endothelin-1 (ET-1). READ MORE