Search for dissertations about: "ETB receptor"

Showing result 16 - 20 of 32 swedish dissertations containing the words ETB receptor.

  2. 16. Endothelial dysfunction in atherosclerosis and type 2 diabetes : clinical and molecular studies of the role of endothelin and arginase

    Author : Arnar Þór Rafnsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background: Atherosclerosis is a modern world scourge and the number of people worldwide diagnosed with type 2 diabetes (T2D) is on the rise, causing much morbidity and mortality. Endothelial dysfunction (ED) is an early sign of atherosclerosis and contributes to vascular complications in T2D. READ MORE

  4. 17. Endothelin-1 in the regulation of vascular function and glucose metabolism in insulin resistance

    Author : Alexey Shemyakin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Insulin resistance plays a major role in the pathogenesis of type 2 diabetes and is an important risk factor for cardiovascular disease. Endothelial dysfunction, characterized by reduced bioactivity of nitric oxide and increased activity of the vasoconstrictor and pro-inflammatory peptide endothelin-1 (ET-1), is present in insulin-resistant states and is an important factor promoting the development of cardiovascular complications in patients with insulin resistance. READ MORE

  5. 18. Splanchnic organ homeostasis in experimental endotoxin shock : with special reference to the endothelin and renin-angiotensin systems

    Author : Anders Oldner; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Endotoxin; endothelin; angiotensin II shock; tonometry microdialysis; porcine; hypoxanthine; gut; splanchnic circulation; lactate; mucosal pHi;

    Abstract : Splanchnic organ homeostasis may become severely deteriorated in states of sepsis and endotoxaemia. Gut tissue hypoxia with subsequent increases in intestinal mucosal permeability has been proposed to contribute to the development of multiple organ failure. READ MORE

  6. 19. Protein Kinase Inhibition in Late Cerebral Ischemia after Subarachnoid Hemorrhage

    Author : Saema Ansar; Lund Medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; neuropsychology; neurophysiology; Neurologi; protein kinase; cerebral ischemia; subarachnoid hemorrage; neurofysiologi; neuropsykologi;

    Abstract : The cerebral ischemia that occur after a subarachnoid hemorrhage (SAH) often results in death or severe disability and is a significant cause of stroke. Our hypothesis is that cerebral ischemia leads to pathophysiological receptor changes on the vascular smooth muscle cells. READ MORE

  7. 20. The role of the endothelin system in experimental acute lung injury : with special reference to the formation of extra-vascular lung water

    Author : Patrik Rossi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Acute lung injury; endothelin-1; extra-vascular lung water; pulmonary capillary pressure; sepsis; pulmonary edema; endotoxin;

    Abstract : Acute lung injury is a major clinical challenge in the intensive care unit. Sepsis is the most frequent underlying cause of this pulmonary syndrome, which contains inflammation-induced diffuse alveolar damage and early stage high permeability edema. READ MORE