Search for dissertations about: "Elementary Flux Mode"

Found 3 swedish dissertations containing the words Elementary Flux Mode.

  2. 1. Macroscopic models of Chinese hamster ovary cell cultures

    Author : Erika Hagrot; Véronique Chotteau; Anders Forsgren; Nathan E. Lewis; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Chinese hamster ovary; Amino acid; Metabolic network; Metabolic flux analysis; Kinetic modeling; Elementary flux mode; Optimization; Column generation; Bioteknologi; Biotechnology;

    Abstract : Biopharmaceuticals treat a range of diseases, and is a growing sector within the pharmaceutical industry. A majority of these complex molecules are produced by genetically modified mammalian cells in large-scale cell cultures. READ MORE

  4. 2. Macroscopic Modeling of Metabolic Reaction Networks and Dynamic Identification of Elementary Flux Modes by Column Generation

    Author : Hildur Æsa Oddsdóttir; Anders Forsgren; Bernhard Palsson; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Metabolic Network; Optimization; Robust Optimization; Least-squares; Column Generation; Modeling; Algorithm; Elementary Flux Mode; Metabolic Flux Analysis; Chinese Hamster Ovary Cell; Amino Acid Metabolism; Tillämpad matematik och beräkningsmatematik; Applied and Computational Mathematics;

    Abstract : In this work an intersection between optimization methods and animal cell culture modeling is considered. We present optimization based methods for analyzing and building models of cell culture; models that could be used when designing the environment cells are cultivated in, i.e., medium. READ MORE

  5. 3. Development of mathematical modelling for the glycosylation of IgG in CHO cell cultures

    Author : Liang Zhang; Véronique Chotteau; Michael J. Betenbaugh; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Chinese hamster ovary cells; glycosylation; IgG; mathematical modelling; experimental design; perfusion; carbon sources; GReBA; Bayesian network; probabilistic graphic model; Bioteknologi; Biotechnology;

    Abstract : Chinese hamster ovary (CHO) cells are the most popular expression system for the production of biopharmaceuticals. More than 80% of the approved monoclonal antibodies (mAbs) or immunoglobulin G (IgG) are produced with these cells. Glycosylation is a usual post- translational modification important for therapeutic mAbs. READ MORE