Search for dissertations about: "Elena Kozlova"

Showing result 1 - 5 of 7 swedish dissertations containing the words Elena Kozlova.

  1. 1. Generation of functional neural progenitors for spinal cord transplantation

    Author : Jan Hoeber; Elena Kozlova; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Regenerative Neurobiology; Stem cells; Sensory regeneration; Spinal cord injury; Neuroscience; Neurovetenskap;

    Abstract : Dorsal root avulsion injuries result in permanent impairment of sensory functions due to the disconnection of the peripheral nervous system from the spinal cord. Strategies aiming for the functional reconnection of sensory neurons with their targets in the spinal cord dorsal horn need to overcome the axonal growth non-permissive glial scar and provide a growth promoting environment. READ MORE

  2. 2. Neural progenitors for sensory and motor repair

    Author : Jan Hoeber; Elena Kozlova; Linda Greensmith; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Regenerative Neurobiology; Stem cells; Sensory regeneration; Spinal cord injury; Amyotrophic Lateral Sclerosis; Neurodegeneration; Oxidative Stress; Medical Science; Medicinsk vetenskap;

    Abstract : Injury and neurodegenerative conditions of the spinal cord can lead to paralysis and loss of sensation. Cell therapeutic approaches can restore sensory innervation of the spinal cord following injury and protect spinal cord cells from degeneration. READ MORE

  3. 3. Reconnecting the CNS and PNS with Stem Cell Transplantation

    Author : Niclas König; Elena Kozlova; Peter Richardson; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; stem cell transplantation; regenerative neurobiology; nerve injury repair; Medical Science; Medicinsk vetenskap;

    Abstract : Severe injury may result in disconnection between the peripheral and central nervous system. Regeneration of the central portion of sensory neurons into the spinal cord is notoriously poor in adult mammals, with low regenerative drive and an unpermissive central environment, most likely resulting in persistent loss of sensory function. READ MORE

  4. 4. The beneficial Effects of Neural Crest Stem Cells on Pancreatic      β–cells

    Author : Anongnad Ngamjariyawat; Elena Kozlova; Leif Jansson; Jens Nielsen; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neural Crest Stem Cells; Pancreatic Islets; β-cell proliferation; β-cell survival; Cadherin; Medical Science; Medicinsk vetenskap;

    Abstract : Patients with type-1 diabetes lose their β-cells after autoimmune attack. Islet transplantation is a co-option for curing this disease, but survival of transplanted islets is poor. Thus, methods to enhance β-cell viability and function as well as methods to expand β-cell mass are required. READ MORE

  5. 5. Neuroprotection in the Injured Spinal Cord : Novel Strategies using Immunomodulation, Stem cell Transplantation and Hyaluronic acid Hydrogel carriers

    Author : Nikos Schizas; Nils Hailer; Elena Kozlova; Mikael Svensson; Uppsala universitet; []
    Keywords : Hyaluronic Acid-based hydrogel; motorneurons; microglial cells; Interleukin-1 Receptor Antagonist; Renshaw cells; excitotoxicity; neuroinflammation; Neural Crest Stem Cells; Medicinsk vetenskap; Medical Science;

    Abstract : The overall aim of this thesis was to establish strategies to minimize secondary damage to the injured spinal cord. Secondary damage that follows spinal cord injury (SCI) involves inflammatory and excitotoxic pathways. READ MORE