Search for dissertations about: "Embryonic stem cell"
Showing result 21 - 25 of 240 swedish dissertations containing the words Embryonic stem cell.
-
21. Modeling Neural Stem Cell and Glioma Biology
Abstract : This thesis is focused on neural stem cell (NSC) and glioma biology. I discuss how NSCs interact with extracellular matrix (ECM) proteins in the stem cell niche, and investigate the consequences of deregulated Platelet-derived growth factor (PDGF) signaling for embryonic NSCs in transgenic mice. READ MORE
-
22. Gene expression studies of pregastrulation development: the basement membrane is essential for cell differentiation
Abstract : Basement membranes (BMs) are sheet-like structures of extracellular matrix. They act as a supporting structure but can also significantly influence cellular behavior in development, tissue homeostasis and disease. Laminins, a major BM component, are multidomain proteins, consisting of three polypeptide chains (α, β and γ). READ MORE
-
23. Roles of the Shb and Cbl Proteins in Signal Transduction and Blood Vessel Formation
Abstract : Formation of blood vessels occurs through two processes: vasculogenesis and angiogenesis, which are regulated by various growth factors such as vascular endothelial growth factor, fibroblast growth factor and platelet-derived growth factor. The present study was carried out in order to investigate the roles of the Shb and Cbl proteins in growth factor-mediated signal transduction and blood vessel formation. READ MORE
-
24. Stem Cell Transplantation in Dorsal Root Injury
Abstract : After traumatic injuries to the brachial plexus there is a risk that one or more of the spinal roots are torn from the spinal cord, known as avulsion injury. This often leads to paralysis and chronic pain, notoriously difficult to treat with current pharmacotherapy. READ MORE
-
25. The Effects of Genetic and Epigenetic Variation on Human Pluripotent Stem Cell Differentiation
Abstract : Human pluripotent stem cells (PSCs) are widely used for studying embryonic development, disease modelling, drug discovery and cell therapy development. Using human PSCs as a model has significantly contributed to our understanding of embryonic development and elucidating novel pathological mechanisms as well as developing new drugs. READ MORE