Search for dissertations about: "Enantioenriched"

Showing result 1 - 5 of 14 swedish dissertations containing the word Enantioenriched.

  2. 1. Enantioenriched Cyanohydrins and Acetoxyphosphonates – Synthesis and Applications

    Author : Robin Hertzberg; Christina Moberg; Frank Glorius; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; asymmetric synthesis; cyanohydrins; acetoxyphosphonates; biocatalyst; titanium catalyst; minor enantiomer recycling; cross-coupling; amino alcohols; Kemi; Chemistry;

    Abstract : In this thesis, the synthesis of enantioenriched compounds using novel methodologies that employ metal- and biocatalysis is described.In the first part, the synthesis of enantioenriched cyanohydrins, which are highly versatile synthetic intermediates, is described. READ MORE

  4. 2. Convergent and Tandem Strategies in Iridium-Catalyzed Asymmetric Hydrogenation of Olefins

    Author : Luca Massaro; Pher Andersson; Antoni Riera; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Enantioconvergent catalysis; asymmetric hydrogenation; iridium catalysis; tandem reaction; mechanistic investigation; Organic Chemistry; organisk kemi;

    Abstract : The work presented in this thesis describes the development of enantioselective methods and their corresponding mechanistic studies to expand the field of catalytic asymmetric hydrogenation. Efficient catalytic systems based on iridium complexes were designed and employed in convergent and tandem strategies to prepare important optically enriched organic compounds. READ MORE

  5. 3. New Methods for Chiral Cyanohydrin Synthesis

    Author : Erica Wingstrand; Christina Moberg; Benjamin List; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; acyl cyanides; asymmetric synthesis; biocatalysis; cyanide; cyanohydrins; dual activation; enzymes; high-throughput screening; Lewis acid; Lewis base; metal catalysis; minor enantiomer recycling; salen; titanium; Chemistry; Kemi;

    Abstract : This thesis deals with method development in asymmetric catalysis and specifically syntheses of enantioenriched O-functionalized cyanohydrins. The first part describes the development of a method for the synthesis of O‑alkoxycarbonylated and O-acylated cyanohydrins. READ MORE

  6. 4. Chemoenzymatic Resolution in Dynamic Systems : Screening, Classification and Asymmetric Synthesis

    Author : Yan Zhang; Olof Ramström; Sabine Flitsch; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; constitutional dynamic chemistry; dynamic systemic resolution; dynamic kinetic resolution; enzyme catalysis; transesterification; enzyme promiscuity; asymmetric synthesis; pattern recognition; self-inhibition.;

    Abstract : This  thesis  is  divided  into  four  parts,  all  centered  around  Constitutional Dynamic  Chemistry  (CDC)  and  Dynamic  Kinetic  Resolution  (DKR)  using biocatalysts for selective transformations, and their applications in screening of bioactive compounds, organic synthesis, and enzyme classification.   In  part  one,  an  introduction  to  CDC  and  DKR  is  presented,  illustrating  the basic  concepts,  practical  considerations  and  potential  applications  of  such dynamic systems, thus providing the background information for the studies in the following chapters. READ MORE

  7. 5. Palladium-Catalyzed Synthesis and Transformation of Organoboranes

    Author : Sara Sebelius; Kálmán J. Szabó; Todd Marder; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; allylborane palladium; Organic chemistry; Organisk kemi; SRA - Molecular Bioscience;

    Abstract : This thesis presents the development of new palladium-catalyzed transformations involving synthesis and application of allylborane reagents. In these reactions various palladium sources, including pincer complexes and commonly used catalysts were applied. READ MORE