Search for dissertations about: "Endocrinology"

Showing result 6 - 10 of 326 swedish dissertations containing the word Endocrinology.

  2. 6. The bank vole (Myodes glareolus) – a novel animal model for the study of diabetes mellitus

    Author : Martin Blixt; Stellan Sandler; Johnny Ludvigsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bank vole; pancreatic islets; diabetes mellitus; hydropic degeneration; proinflammatory cytokine; Diabetology; Diabetologi; Endocrinology; Endokrinologi; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : The bank vole (Microtus arvalis) develops glucose intolerance both when kept in captivity and in the wild state. Glucose intolerant bank voles kept in captivity exhibited polydipsia, polyuria, hyperglycemia, hyperinsulinemia, islet autoantibodies and a markedly changed islet structure resembling so–called hydropic degeneration. READ MORE

  4. 7. Antigen-specific islet antibodies: prediction of beta cell failure and differentiation between Type 1 and Type 2 diabetes

    Author : Henrik Borg; Malmö Institutionen för kliniska vetenskaper; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetology; Endokrinologi; secreting systems; Endocrinology; seropositive; seronegative; slowly-progressive; Type 2; Type 1; classification; IA-2A; IA-2; GADA; GAD; ICA; islet antibodies; C-peptide; beta cell function; diabetes mellitus; adult-onset; sekretion; diabetologi;

    Abstract : Autoantibodies against glutamic acid decarboxylase (GADA), protein tyrosine-phosphatase-like protein (IAÐ2A), and/or pancreatic islet cells (ICA) are autoimmune markers usually present at diagnosis of Type 1 diabetes. Type 1 diabetes is therefore in general believed to be caused by an immune-mediated beta cell destruction. READ MORE

  5. 8. Sex differences in immune response and sex hormone receptor expression in healthy individuals and during viral infection

    Author : Peik M. A. Brundin; Anders F. Johansson; Ivan Nalvarte; Carl-Johan Treutiger; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; immune response; menstrual cycle; puumala virus; hantavirus; torque teno virus; sex hormones; sex hormone receptors; estrogen receptors; estrogen receptor beta2; sex differences; microbiome; virome; endocrinology; peripheral blood mononuclear cells; qPCR; Infectious Diseases; infektionssjukdomar; medicinsk virologi; Medical Virology; immunologi; Immunology; Medical Cell Biology; medicinsk cellbiologi; molekylärbiologi; Molecular Biology; Medicine; medicin; obstetrik och gynekologi; Obstetrics and Gynaecology;

    Abstract : There is sex-bias in morbidity and mortality from infectious diseases. Infections kill more men than women and several studies have pointed out differences in the immune system as a reason. The sex hormones estrogen, progesterone and testosterone all shape the effect of the immune response on multiple levels. READ MORE

  6. 9. Common variants in genes regulating free fatty acid metabolism and risk of type 2 diabetes and cardiovascular disease

    Author : Martin Carlsson; Malmö Institutionen för kliniska vetenskaper; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cardiovascular disease; free fatty acids; genetics; UCP1; beta3-adrenergic receptor; beta2-adrenergic receptor; type 2 diabetes mellitus; FABP2; stroke; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

    Abstract : Abstract The present study evaluated genetic and metabolic factors influencing the risk for type 2 diabetes and cardiovascular disease (CVD) with special reference to increased concentrations of free fatty acids (FFA) in 1174 Swedish diabetic and nondiabetic subjects. Common polymorphisms in the fatty acid binding protein 2 (FABP2), the B2-adrenergic receptor (B2-AR), the B3 -adrenergic receptor (B3-AR) and the uncoupling protein 1 (UCP-1) genes were related to anthropometric and metabolic variables. READ MORE

  7. 10. Genetics of diabetic subtypes

    Author : Camilla Cervin; Diabetes - klinisk obesitasforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endocrinology; secreting systems; diabetology; Endokrinologi; Mutation; Association; Genetics; LADA; Diabetes; MODY; sekretion; diabetologi;

    Abstract : There are two major types of diabetes mellitus, Type 1 Diabetes (T1D) and Type 2 Diabetes (T2D), however a number of subtypes have been defined and classified. Maternally Inherited Diabetes and Deafness (MIDD) and Maturity Onset Diabetes of the Young (MODY) are monogenic forms, whereas Latent Autoimmune Diabetes in Adults (LADA) is thought to be a polygenic subtype similar to T1D. READ MORE