Search for dissertations about: "Endoglin"

Showing result 1 - 5 of 8 swedish dissertations containing the word Endoglin.

  1. 1. THE ROLE OF BMP SIGNALING AND ENDOGLIN IN REGULATION OF HEMATOPOIESIS

    University dissertation from Department of Molecular Medicine and Gene Therapy, Lund University

    Author : Sofie Singbrant; Lund University.; Lunds universitet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGF-beta superfamily signaling; Conditional knockout mouse; Hematopoietic Stem Cell; Hematopoiesis; Endoglin; BMP;

    Abstract : Hematopoiesis, the formation of blood cells, ultimately depends on a rare population of hematopoietic stem cells (HSCs), which can both self-renew to maintain the HSC pool, and differentiate into all mature blood lineages. HSC fate decisions are governed by a complex combination of numerous signals, although the molecular mechanisms are not fully understood. READ MORE

  2. 2. THE ANGIOGENIC RESPONSE IN HYPOXIC HEART. Experimental studies in mice

    University dissertation from Department of Molecular Medicine and Gene Therapy, Lund University

    Author : Fei Tian; Göteborgs universitet.; Gothenburg University.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hypoxia; angiogenesis; mice; endoglin; SUMO; PDI;

    Abstract : Coronary artery disease is the leading cause of death in the western world today. Although induction of angiogenesis would appear to be an ideal therapeutic strategy, clinical trials of proangiogenic factors have proved disappointing. READ MORE

  3. 3. Prognostic markers in prostate cancer studies of a watchful waiting cohort with long follow up

    University dissertation from Umeå : Umeå universitet

    Author : Andreas Josefsson; Umeå universitet.; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; Immunohistochemistry; Prognostic markers; biomarkers; Survival analysis; human; pathology; watchful waiting; tissue micro array; Endoglin; von willebrandt factor; ki67; ki-67; hyaluronan; patologi; Pathology;

    Abstract : Background: Prostate Cancer (PC) is a common and highly variable disease. Using current diagnostic methods, the prostate specific antigen (PSA) blood test and histological grading of prostate tissue needle biopsies, it is often difficult to evaluate whether the patient has a PC that requires active treatment or not. READ MORE

  4. 4. Angiogenesis in human renal cell carcinoma hypoxia, vascularity and prognosis

    University dissertation from Umeå : Strålningsvetenskaper

    Author : Johanna Sandlund; Umeå universitet.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endoglin CD105; CD31; prognosis; CA IX; HIF-2α; renal cell carcinoma; tissue microarray; immunohistochemistry; real-time PCR; stage; grade; MEDICINE Surgery Oncology; MEDICIN Kirurgi Onkologi;

    Abstract : Background: Angiogenesis is recognised as a critical step in tumour progression. The angiogenic switch is activated by various trigger signals, such as hypoxia, low pH, and genetic mutations. Renal cell carcinoma (RCC) is often an aggressive tumour, and advanced disease has limited treatment options and bad prognosis. READ MORE

  5. 5. Exploring the potential of antiangiogenic strategies targeting the TGF-β family in the tumor microenvironment

    University dissertation from Stockholm : Karolinska Institutet, Dept of Medical Biochemistry and Biophysics

    Author : Sara Cunha; Karolinska Institutet.; Karolinska Institutet.; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Members of the transforming growth factor (TGF)-β family exert their effect on virtually all cell types in the body, producing diverse and complex cellular responses. Additionally, TGF-β signaling is deregulated and hyperactive in many malignant conditions, making it an appealing target in the combat of cancer disease. READ MORE