Search for dissertations about: "Endoglin"
Showing result 6 - 9 of 9 swedish dissertations containing the word Endoglin.
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6. Exploring the potential of antiangiogenic strategies targeting the TGF-β family in the tumor microenvironment
Abstract : Members of the transforming growth factor (TGF)-β family exert their effect on virtually all cell types in the body, producing diverse and complex cellular responses. Additionally, TGF-β signaling is deregulated and hyperactive in many malignant conditions, making it an appealing target in the combat of cancer disease. READ MORE
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7. Small talk in the tumor microenvironment : the contribution of fibroblasts and endothelial cells to the malignant phenotype
Abstract : Cancer is the result of aberrant cells developing into tumor cells that act in concert with the micro- and macroenvironment like any other organ in our bodies. The cells and molecules of the tumor microenvironment are important contributors to the tumorigenic process. READ MORE
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8. TGF-β Family Signaling in Tumor Angiogenesis
Abstract : Angiogenesis provides growing tumors a source of nutrients and oxygen, and a route for metastatic dissemination. In recent years anti-angiogenic therapies that primarily target the vascular endothelial growth factor (VEGF) signaling cascade have entered the clinic. READ MORE
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9. Angiogenesis in myeloproliferative disorders
Abstract : The chronic myeloproliferative disorders, comprising polycythemia vera (PV), essential thrombocytosis (ET), chronic myeloid leukaemia (CML) and myelofibrosis (MF), are all characterized by pathological angiogenesis in variable degrees, e.g. increased microvascular density (MVD) and bizarre vessel architecture. READ MORE
