Search for dissertations about: "Endosomal escape"

Showing result 1 - 5 of 16 swedish dissertations containing the words Endosomal escape.

  2. 1. Naturally derived cell-penetrating peptides and applications in gene regulation : A study on internalization mechanisms and endosomal escape

    Author : Pontus Lundberg; Ülo Langel; Bernard Lebleu; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; peptide; oligonucleotide; endocytosis; gene regulation; Neurochemistry; Neurokemi;

    Abstract : Cell-penetrating peptides are a class of peptides which have achieved a lot of recognition due to their vector abilities. Since their discovery over a decade ago, there has been an uncertainty concerning the mechanism by which they are internalized into the cells. READ MORE

  4. 2. Mechanisms for immune escape in epithelial ovarian cancer

    Author : Pernilla Israelsson; Ulrika Ottander; Lucia Mincheva-Nilsson; Eva Lundin; Ivan Nagaev; Karin Sundfeldt; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human; ovarian cancer; high-grade serous cancer; EOC; HGSC; HGSOC; tumor microenvironment; immune escape; immune suppression; cytokines; exosomes; NKG2D; MICA B; ULBP1-3; DNAM-1; surgery; obstetrik och gynekologi; Obstetrics and Gynaecology;

    Abstract : Tumors develop mechanisms to subvert the immune system, constituting immune escape. Epithelial ovarian cancer (EOC), the deadliest of all gynecological malignancies, uses a variety of mechanisms to undermine immune surveillance, aiding its establishment and metastatic spreading. READ MORE

  5. 3. Detection and quantification of lipid-mediated siRNA delivery to the cytosol

    Author : Hampus Hedlund; Tumörmikromiljö; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; RNA Interference; RNA Therapeutics; Endosomal Escape; Lipid Mediated Delivery; Live-Cell Imaging;

    Abstract : Cancer is one of the leading causes of death globally. Novel therapeutics is urgently needed to advance treatment, especially for generalized disease where current treatment options have a poor prognosis. In particular, targeted therapy that can address genetic changes would be of great value. READ MORE

  6. 4. Biophysical studies of peptides with functions in biotechnology and biology

    Author : Fatemeh Madani; Astrid Gräslund; Steven F. Dowdy; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Genetic fluorescence label; Biarsenical tetracysteine motif; Cell-penetrating peptides; Large unilamellar vesicles; Pyrenebutyrate; Endosomal escape; Membrane perturbation; Bacteriorhodopsin; Dynorphin; Biophysics; biofysik;

    Abstract : My thesis concerns spectroscopic studies (NMR, CD and fluorescence) of peptides with functions in biotechnology and biology, and their interactions with a model membrane (large unilamellar phospholipid vesicles).The resorufin-based arsenical hairpin binder (ReAsH) bound to a short peptide is a useful fluorescent tag for genetic labeling of proteins in living cells. READ MORE

  7. 5. Oligonucleotide Complexes with Cell-Penetrating Peptides : Structure, Binding, Translocation and Flux in Lipid Membranes

    Author : Luis Daniel Ferreira Vasconcelos; Ülo Langel; Tore Bengtsson; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell-penetrating peptide; Large unilamellar vesicle; Membrane perturbation; Endosomal escape; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : The ability of cell-penetrating peptides to cross plasma membranes has been explored for various applications, including the delivery of bioactive molecules to inhibit disease-causing cellular processes. The uptake mechanisms by which cell-penetrating peptides enter cells depend on the conditions, such as the cell line the concentration and the temperature. READ MORE