Search for dissertations about: "Endosomes"
Showing result 1 - 5 of 41 swedish dissertations containing the word Endosomes.
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1. Lysosomal network proteins as biomarkers and therapeutic targets in neurodegenerative disease
Abstract : The pre-symptomatic stage of neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) occurs several decades before the clinical onset. Changes in the lysosomal network, i.e. the autophagosomal, endosomal and lysosomal vesicular system, are among the first alterations observed. READ MORE
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2. The synaptic and neurobiological role of apolipoprotein E4 in models of Alzheimer's disease
Abstract : .... READ MORE
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3. Systemic RNAi Relies on the Endomembrane System in Caenorhabditis elegans
Abstract : The membrane system of a eukaryotic cell is a large and complex system handling the transport, exchange and degradation of many kinds of material. Recent research shows that double-stranded RNA (dsRNA) mediated gene silencing (RNA interference) is a membrane related process. READ MORE
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4. Connecting Systemic RNAi to the Endomembrane System in Caenorhabditis elegans
Abstract : RNA interference (RNAi) is a gene regulation mechanism conserved among eukaryotes. To silence gene expression, RNAi relies on a short single-stranded guide RNA to steer the RNA-induced Silencing Complex (RISC) to mRNAs with guide strand-complementary sequences. RNAi is a highly membrane-associated process. READ MORE
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5. Role of syntaxin-11 and munc18-2 in lymphocyte cytotoxic granule exocytosis
Abstract : Mutations in genes required for the exocytosis of cytotoxic granules by NK cells and cytotoxic T lymphocytes are associated with early-onset familial hemophagocytic lymphohistiocytosis (FHL). In this project, we examined how certain missense mutations in genes encoding syntaxin-11 and Munc18-2 abolish exocytosis and cause disease. READ MORE