Search for dissertations about: "Endotoxin"

Showing result 21 - 25 of 144 swedish dissertations containing the word Endotoxin.

  2. 21. Acute lung injury : study of pathogenesis and therapeutic interventions

    Author : David Rocksén; Anders Bucht; Thomas Sandström; Johan Grunewald; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; ALI; ARDS; Dexamethasone; N-acetylcysteine; Vitamin E; LPS; Endotoxin; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin; lungmedicin; Lung Medicine;

    Abstract : .... READ MORE

  4. 22. Pharmacometrics to characterize innate immune response and antibacterial treatments

    Author : Anders Thorsted; Lena E. Friberg; Elisabet I. Nielsen; Mats O. Karlsson; Gauri G. Rao; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; non-linear mixed effects modelling; modelling; pharmacokinetics; pharmacodynamics; pkpd; antibiotics; cefuroxime; piperacillin; phagocytes; lipopolysaccharide; endotoxin; porcine endotoxemia; challenge studies; sepsis; critically ill; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : The immune system protects the host against pathogens by distinguishing self from non-self. However, it is most-often disregarded in pharmacokinetic-pharmacodynamic (PKPD) characterization of (new and old) antibiotics. READ MORE

  5. 23. Oxygen delivery and mitochondrial dysfunction as assessed by microdialysis during interventions in experimental sepsis

    Author : Magnus von Seth; Lipscey Miklós; Jan Sjölin; Mats Eriksson; Jukka Takala; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; sepsis; animal models; microdialysis; endotoxin; Escherichia coli; tigecycline; doxycycline; albumins; capillary leak syndrome; lactic acid; oxygen delivery; multiple organ failure; mitochondria; tumor necrosis factor alpha; interleukin-6; cyanides; ouabain; Anestesiologi och intensivvård; Anaesthesiology and Intensive Care;

    Abstract : Early administration of broad-spectrum antibiotics is the first goal in sepsis treatment. Besides from bacteriostatic/bactericidal effects, some antibiotics may also modify the host´s response to infection. The novel antibiotic tigecycline may exert such properties; however, this property has not been evaluated in large-animal trials. READ MORE

  6. 24. Endotoxin-induced inflammation in healthy human airways

    Author : Margaretha E. Smith; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LPS; neutrophils; bronchoalveolar lavage; human airways; innate immunity;

    Abstract : The aim of this thesis was to investigate the innate immune response in healthy human airways in vivo after simulation of a Gram-negative infection. Intrabronchial exposure to the TLR4 agonist endotoxin was used as a model for the innate mechanisms in the immune response that are caused by cigarette smoke and by natural infection with Gram-negative bacteria. READ MORE

  7. 25. Immune responses to lipopolysaccharide in relation to allergic disease : a TLR4 gene polymorphism and endotoxin exposure

    Author : Anna Lundberg; Malin Fagerås Böttcher; Outi Vaarala; Marita Troye-Blomberg; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Background: Allergic diseases have increased during the last decades, particularly in affluent countries, possibly due to a reduced and/or altered microbial exposure during infancy. Activation of the immune system by microbes early in life is probably required for accurate maturation of the immune system and tolerance development. READ MORE