Search for dissertations about: "Enterovirus"
Showing result 1 - 5 of 30 swedish dissertations containing the word Enterovirus.
-
1. Enterovirus Infections of β-Cells : A Mechanism of Induction of Type 1 Diabetes?
Abstract : The process of β-cell destruction that leads to type 1 diabetes (T1D) is incompletely understood and it is believed to be a result of both genetic and environmental factors. Enterovirus (EV) infections of the β-cells have been proposed to be involved, however, the effects of EV infections on human β-cells have been little investigated. READ MORE
-
2. Reverse genetic studies of Enterovirus replication
Abstract : Enteroviruses belong to the Picornaviridae family and are small icosahedral viruses with RNA genomes of positive polarity, containing a single open reading frame. They mostly cause mild or asymptomatic infections, but also a wide array of diseases including: poliomyelitis, encephalitis, gastroenteritis, aseptic meningitis, myocarditis, hand-foot-and-mouth disease, hepatitis and respiratory diseases, ranging from severe infections to the common cold. READ MORE
-
3. Tissue tropism and oncolytic potential of enteroviruses
Abstract : .... READ MORE
-
4. Enterovirus Implications in Type 1 Diabetes
Abstract : Human enteroviruses (HEVs), particularly Coxsackie B viruses (CVBs), might trigger the onset of type 1 diabetes (T1D), either by direct infection of the insulin-producing beta-cells or by an indirect inflammatory response. The overall aim of this thesis was to study the tropism of HEVs in isolated human pancreatic cell clusters in vitro including virus effects on islet function, gene-expression and ultrastructure. READ MORE
-
5. Inflammatory Mediators and Enterovirus Infections in Human Islets of Langerhans
Abstract : Type 1 diabetes (T1D) is due to a selective loss of the insulin producing β-cells. However, the process responsible for this loss is still unknown. There is accumulating evidence that enteroviruses (EVs) are involved in T1D. In addition to direct virus-induced cytolysis, EVs could facilitate β-cell destruction by inducing inflammatory cytokines. READ MORE