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Showing result 1 - 5 of 10 swedish dissertations matching the above criteria.

  2. 1. Studies on Tissue Factor with Focus on Cell Signaling and Cancer

    Author : Oskar Eriksson; Agneta Siegbahn; Lina Badimon; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tissue Factor; blood coagulation; cell signaling; protease; mass spectrometry; immunohistochemistry; colorectal cancer; apoptosis; Eph receptor; Klinisk kemi; Clinical Chemistry; Molekylär cellbiologi; Molecular Cellbiology;

    Abstract : This thesis have explored the functions of the protein Tissue Factor (TF), which together with its ligand coagulation factor VII/VIIa (FVII/FVIIa) forms a proteolytic complex that functions in initiation of blood coagulation and activation of cell signaling.In paper I, the mechanisms behind the observation that TF/FVIIa signaling protects cells from apoptosis were further investigated. READ MORE

  4. 2. Spatial regulation of membrane receptor signaling using DNA origami

    Author : Trixy Fang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Juxtracrine signaling between apposing membrane receptors and ligands is an important class of intercellular communication. Much focus has been directed towards studying the biochemical interactions between receptors and ligands, their surface expression levels and signaling activities for driving downstream signaling processes. READ MORE

  5. 3. Ephrin and Eph-receptor growth factor signaling in non small cell lung cancer : identification of biomarkers and therapeutic targets

    Author : Ghazal Efazat; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Non-small cell lung cancer (NSCLC) is the main subtype of lung cancer (LC) and unfortunately it responds very poorly to conventional chemo- and radiotherapy (RT). Moreover, NSCLC is often diagnosed at a stage where metastases are found and only for a limited number of NSCLC tumors targeted therapies can be used as their oncogenic drivers remains elusive. READ MORE

  6. 4. Ephrins off the beaten path

    Author : Johan Holmberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The Orchestration of cell-cell interactions is crucial to the developing embryo and the adult organism. Intercellular communication is to a large extent controlled by signalling events downstream of receptor tyrosine kinases (RTKs). Ligands for RTKs are often soluble and confer long distance information to the receptor expressing cell. READ MORE

  7. 5. Structural studies of three cell signaling proteins : crystal structures of EphB1, PTPA, and YegS

    Author : Amin Bakali; Pär Nordlund; Wenqing Xu; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; protein production; structural genomics; cell signaling; Biochemistry; Biokemi;

    Abstract : Kinases and phosphatases are key regulatory proteins in the cell. The disruption of their activities leads ultimately to the abolishment of the homeostasis of the cell, and is frequently correlated with cancer. EphB1 is a member of the largest family of receptor tyrosine kinases. It is associated with neurogenesis, angiogenesis, and cancer. READ MORE