Search for dissertations about: "Eph receptor"
Showing result 6 - 10 of 10 swedish dissertations containing the words Eph receptor.
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6. Applications of DNA origami encoded nanoscale patterns
Abstract : It was almost four decades ago when the recognition of DNA’s potential use as a programmable, self-assembling building material for nanostructures led to the birth and rapid expansion of the field of DNA nanotechnology, but it was two decades later when the development of the DNA origami technique initiated the widespread use of DNA based nanoconstructs through the simplification of the design process and the reduction of the required control over the quality and stoichiometry of the assembly components by using a single-stranded “scaffold” DNA and a set of “staple” oligonucleotides that “fold” the mentioned scaffold DNA into a predesigned shape by binding different regions of the scaffold strand together. This robust approach not only permitted the construction of intricate two- and three-dimensional structures, but it also allowed the design and fabrication of molecular patterns with unprecedented accuracy as each functionalizible component’s relative position in the DNA origami structure is known to nanometer precision. READ MORE
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7. Biophysical regulation of cell function : the yin and yang of the microenvironment
Abstract : From embryonic development to tissue regeneration and disease progression, the human body is continuously subject to mechanical stresses. Physical forces are increasingly recognized as major microenvironmental cues that control tensional homeostasis in tissues. READ MORE
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8. No guts, no glory : EphB mediated signaling in intestinal stem and progenitor cells
Abstract : The work presented in this thesis is focused on the intestinal stem cell niche, the crypts, and the Eph tyrosine kinase receptors together with their ligands that are expressed by the crypt epithelial progenitor cells. Two fundamental cellular processes, high turnover coupled to a rapid ordered migration of the newborn cells out from the crypt, characterize the normal intestine. READ MORE
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9. From Tissue to Mutations : Genetic Profiling of Colorectal Cancer
Abstract : Comprehensive characterisation of the mutational landscapes of solid tumours is a multistep process involving the collection of suitable samples, the extraction of nucleic acids and the preparation of these materials for mutational analyses. In this thesis, I aimed to develop a streamlined process for the analysis of colorectal cancer (CRC) patient samples in order to identify novel mutations that hallmark the development of advanced disease. READ MORE
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10. Prognostic and Predictive Somatic Mutations in Colorectal Cancer
Abstract : Colorectal cancer (CRC) is the third most incident and the second deadliest cancer worldwide. Even though CRC incidence is strongly correlated with age, it has been increasing in developing countries and younger individuals. READ MORE
