Search for dissertations about: "Epidermis"

Showing result 1 - 5 of 94 swedish dissertations containing the word Epidermis.

  1. 1. Kallikrein-related peptidases in human epidermis studies on activity, regulation, and function

    University dissertation from Umeå : Dermatologi och venereologi

    Author : Kristina Stefansson; Umeå universitet.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; desquamation; epidermis; stratum corneum; kallikrein-related peptidase; KLK; serine protease inhibitors; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Dermatology and venerology; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Dermatologi och venerologi;

    Abstract : Introduction. The outermost layer of the epidermis, the stratum corneum (SC), plays a fundamental role in our defense against microorganisms, chemicals, and dehydration. The SC is composed of tightly packed keratinized skin cells, corneocytes. For a functioning skin it is essential that corneocytes are constantly shed (desquamated). READ MORE

  2. 2. DNA Damage Response of Normal Epidermis in the Clinical Setting of Fractionated Radiotherapy Evidence of a preserved low-dose hypersensitivity response

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Fredrik Qvarnström; Uppsala universitet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA damage response; low-dose hypersensitivity; dose response; normal tissue; epidermis; keratinocyte; fractionated radiotherapy; DNA double strand break; DSB; foci; γH2AX; 53BP1; checkpoint; p21; apoptosis; mitosis; MEDICINE Surgery Oncology; MEDICIN Kirurgi Onkologi; Oncology; onkologi;

    Abstract : Investigations of DNA damage response (DDR) mechanisms in normal tissues have implications for both cancer prevention and treatments. The accumulating knowledge about protein function and molecular markers makes it possible to directly trace and interpret cellular DDR in a tissue context. READ MORE

  3. 3. In vitro Studies of Genodermatoses Affecting Cytoskeletal Integrity and Lipid Processing in Human Epidermis Pathogenic Mechanisms and Effects of Retinoid Therapy

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Hao Li; Uppsala universitet.; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Congenital Ichthyosiform Erythroderma; Epidermolytic Hyperkeratosis; Ceramides; Keratins; Retinoids; Molecular Probe Techniques; Transglutaminases; Lipoxygenases; Fatty Acid Transporter Proteins; Keratinocytes; Epidermis; Medicinsk vetenskap; Medical Science;

    Abstract : Autosomal dominant epidermolytic ichthyosis (EI) is a rare disease characterized by intra-epidermal blistering due to mutations in either of two keratin genes, KRT1 and KRT10, expressed by suprabasal keratinocytes. Autosomal recessive congenital ichthyosis (ARCI) is a non-blistering, hyperkeratotic disease caused by mutations in one of the following genes: ABCA12, ALOX12B, ALOXE3, TGM1, CYP4F22, NIPAL4 and SLC27A4, which are all essential for skin barrier homeostasis. READ MORE

  4. 4. Retinoic Acid Metabolism Blocking Agents and the Skin In vivo and in vitro Studies of the Effects on Normal and Diseased Human Epidermis

    University dissertation from Uppsala : Universitetsbiblioteket

    Author : Elizabeth Pavez Loriè; Uppsala universitet.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CYP; CYP26; retinoids; vitamin A; RAMBA; metabolism; keratinocyte; epidermis; retinoid regulated genes; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Dermatology and venerology; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Dermatologi och venerologi;

    Abstract : Retinoic Acid Metabolism Blocking Agents (RAMBAs) increase the endogenous levels of all-trans retinoic acid (RA) by inhibiting CYP26 enzymes. Thus they are believed to mimic the effects of retinoid treatment. Their mechanism of action and effects on vitamin A metabolism in keratinocytes are however uncertain. READ MORE

  5. 5. Epidermal Reactions to Injury with Implications for Innate Immunity

    University dissertation from Department of Clinical Sciences, Lund University

    Author : Markus Roupé; Lunds universitet.; Lund University.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Innate immunity; epidermis; Wound healing; interleukin-8; Antimicrobial peptides;

    Abstract : Popular Abstract in Swedish En värld av mikrober Vi lever i en värld full av olika bakterier och svampar, så kallade mikrober. Med tanke på artrikedomen och mängden av infektiösa mikrober vi dagligen kommer i kontakt med kan det nästan tyckas som ett smärre mirakel att vi trots allt är så friska som vi är. READ MORE