Search for dissertations about: "Epithelial Cells : metabolism"

Showing result 1 - 5 of 71 swedish dissertations containing the words Epithelial Cells : metabolism.

  2. 1. Regulation of the cytoskeleton and the adhesiveness of intestinal epithelial cells by leukotriene D4

    Author : Ramin Massoumi; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Cytology; patologisk anatomi; Patologi allmän ; pathological anatomy; General pathology; PKC; vinculin; actin filament; focal adhesion; LTD4; integrin; cancerology; Cytologi; onkologi; cancer; Biochemistry; Metabolism; Biokemi; metabolism;

    Abstract : Leukotrienes belong to a family of biologically active conjugated trienes that are formed from arachidonic acid via the 5-lipoxygenase pathway and are important mediators of inflammatory reactions. The CysLT1 receptor that specifically serves as receptor for leukotriene D4 (LTD4) has been identified as a G-protein coupled receptor. READ MORE

  4. 2. Arachidonic acid metabolism in corneal epithelial cells : Identification of lipoxygenase isoforms

    Author : Maria Liminga; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Cornea; cDNA cloning; lipoxygenase; liquid chromatography-mass spectrometry; organ culture; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; farmaceutisk farmakologi; Pharmaceutical Pharmacology;

    Abstract : The metabolism of arachidonic acid in the human cornea was investigated and compared with the metabolism in cattle and primates. All three species showed significant arachidonic acid metabolism inthe epithelium, whereas the activity in the stroma and the endothelium was low or undetectable. READ MORE

  5. 3. The interplay between Giardia intestinalis and host intestinal epithelial cells : A tale of immune activation and suppression

    Author : Jana Grüttner; Staffan Svärd; Mikael E. Sellin; Steven Singer; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Giardia; diarrhea; RNAseq; proteomics; small intestinal epithelial cells; enteroids; organoids; protozoan; differentiation; immune response; host-parasite interaction; swimming; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

    Abstract : Giardia intestinalis is a non-invasive, protozoan parasite causing the diarrheal disease giardiasis in a variety of mammals, including humans. The parasite has two main life cycle stages; disease-causing trophozoites and infectious cysts. Trophozoites colonize the host’s upper small intestine by attaching to intestinal epithelial cells (IECs). G. READ MORE

  6. 4. Influence of hypoxia on differentiation and proliferation of non-malignant and tumor cells

    Author : Marica Vaapil; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hypoxia; breast cancer; EPOR; small cell lung carcinoma; differentiation; proliferation; metabolism;

    Abstract : Solid tumors are less oxygenated than their tissue of origin. Low intra-tumor oxygen levels are associated with worse outcome, increased metastatic potential and immature phenotype in breast cancer. We have reported that tumor hypoxia correlates to low differentiation status in breast cancer. READ MORE

  7. 5. Prognostic role of the tumour microenvironment in esophago-gastric, pancreatic and periampullary adenocarcinoma: B cells and beyond

    Author : Richard Fristedt; Tumörmikromiljö; []
    Keywords : Polymeric immunoglobulin receptor; B cells; Plasma cells; Esophageal adenocarcinoma; gastric adenocarcinoma; Pancreatic ductal adenocarcinoma; Periampullary adenocarcinoma; Prognosis and survival; Immune system;

    Abstract : Cancer development depends on cells aquiring a skillset of limitless growth and finally invasive properties to allow for metastasis, as summarised by the six hallmarks of cancer. Recently four more hallmarks have been added: genomic instability, deregulating cellular metabolism, tumour-promoting inflammation and avoiding immune destruction. READ MORE