Search for dissertations about: "Epitope prediction"

Showing result 1 - 5 of 9 swedish dissertations containing the words Epitope prediction.

  2. 1. Computational Prediction Models for Proteolytic Cleavage and Epitope Identification

    Author : Liwen You; Beräkningsbiologi och biologisk fysik - Genomgår omorganisation; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; medical informatics; biomathematics biometrics; Bioinformatics; SVM; sequence analysis; rule extraction; protease-peptide interaction; OSRE; MHC; immunology; HIV; hierarchical method; HCV; Gaussian process; false positive; epitope; cleavage specificity; cleavage prediction; binding affinity; caspase; Bioinformatik; medicinsk informatik; biomatematik; Computer science; numerical analysis; systems; control; Datalogi; numerisk analys; system; kontroll; Binding affinity; Bioinformatics;

    Abstract : The biological functions of proteins depend on their physical interactions with other molecules, such as proteins and peptides. Therefore, modeling the protein-ligand interactions is important for understanding protein functions in different biological processes. READ MORE

  4. 2. Selection of antigens for antibody-based proteomics

    Author : Lisa Berglund; Mathias Uhlén; Sören Brunak; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; epitope; antigen; antibody; affinity; protein; proteome; proteomics; bioinformatics; prediction; primer design; sequence similarity; Bioengineering; Bioteknik;

    Abstract : The human genome is predicted to contain ~20,500 protein-coding genes. The encoded proteins are the key players in the body, but the functions and localizations of most proteins are still unknown. READ MORE

  5. 3. Humoral immunity to recombinant human autoantigens in organ-specific autoimmune disease

    Author : Alberto Falorni; Karolinska Institutet; Karolinska Institutet; []
    Keywords : IDDM; Addison s disease; autoantibodies; recombinant autoantigens; radioimmunoassay; disease prediction; glutamic-acid decarboxylase; steroid-21-hydroxylase;

    Abstract : Insulin-dependent diabetes mellitus (IDDM) and idiopathic Addison's disease are organ-specific autoimmune diseases characterized by the presence of circulating autoantibodies. The role of autoantibodies in the pathogenesis of these diseases is not fully understood, but their presence can be used as a marker for diagnosis and prediction. READ MORE

  6. 4. Genetic studies of the HLA locus in rheumatic diseases

    Author : Emeli Lundström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) share a complex etiology consisting of both genetic and environmental components. Stimulation of lymphocytes and various other immune cells, release of cytokines, activation of complement and production of autoantibodies due to loss of tolerance to self-antigens, contributes to the pathogenesis of both RA and SLE. READ MORE

  7. 5. IL-25 and B cells in atherosclerosis

    Author : Polyxeni Mantani; Kardiovaskulär forskning - immunitet och ateroskleros; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IL-25; B cells; ILC2s; IL-5; anti-PC IgM; atherosclerosis; stroke; cardiovascular events;

    Abstract : Atherosclerosis is a chronic inflammatory disease of medium and large vessels of the body which is mainly characterized by the formation of lipid rich plaques within the arterial tissue. It is the most common cause of cardiovascular disease leading to clinical manifestations of coronary artery and cerebrovascular disease. READ MORE