Search for dissertations about: "ErbB2"

Showing result 11 - 15 of 26 swedish dissertations containing the word ErbB2.

  2. 11. MicroRNAs in HER2-Amplified Breast Cancer

    Author : Inga Newie; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; miR-21; PAPD5; Breast Cancer; miR-4728; microRNA; ERBB2 HER2;

    Abstract : Background: Breast cancer is the most common female malignancy and the leading cause of cancer-related deaths worldwide. Targeted therapy against the main biomarkers estrogen receptor alpha (ER) and human epidermal growth factor receptor 2 (HER2/ERBB2) have greatly improved mortality rates, but ab initio or acquired therapy resistance is common. READ MORE

  4. 12. Breast cancer : Multifocality, heterogeneity, and related genetic signatures

    Author : Gyula Pekar; Dumanski Jan; Sapino Anna; Uppsala universitet; []
    Keywords : breast; breast cancer multifocality; molecular phenotypes; intertumoral heterogeneity; biobanking; gene copy number aberrations;

    Abstract : Breast carcinoma often exhibits a complex subgross morphology and may occupy a large volume of the breast tissue and show unifocal, multifocal or diffuse growth patterns. Expression of estrogen- and progesterone receptors, HER2 overexpression, tumor grade, and proliferative activity allows us to classify breast carcinoma into molecular subgroups (Luminal A, Luminal B, HER2-type, triple negative, and basal-like). READ MORE

  5. 13. Genetic determinants of postmenopausal breast and endometrial cancer

    Author : Kristjana Einarsdóttir; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Breast cancer is overall the most common cancer in women worldwide and endometrial cancer is the most common gynaecological cancer in the industrialized world. History of a first-degree relative with breast or endometrial cancer has been related to a twofold increase in risk of the respective diseases. READ MORE

  6. 14. Expression and prognostic value of LRIG1 and the EGF-receptor family in renal cell and prostate cancer

    Author : Marcus Thomasson; Håkan Hedman; Roger Henriksson; Börje Ljungberg; Sten Nilsson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; Renal cell carcinoma; EGFR; ErbB1-4; LRIG1; Oncology; Onkologi; onkologi; Oncology;

    Abstract : The epidermal growth factor receptor (EGFR) family consists of four (EGFR, ErbB2, Erbb3, and ErbB4) receptor tyrosine kinases (RTK) whose signalling is important for physiological and malignant cellular functions such as proliferation, survival, migration, and differentiation. EGFR and ErbB2 in particular are established oncogenes in many solid tumours and are targets for anti-cancer treatment. READ MORE

  7. 15. Molecular and cytogenic studies of oncogene alterations in human breast and cervical carcinomas

    Author : Anju Zhang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Breast cancer; cervical cancer; oncogene; gene amplification; hTERT;

    Abstract : Characterization of human tumors with associated genetic changes is of importance for better understanding the tumor's basic biological behavior and of great value for clinical management of cancer patients. We therefore investigated oncogene amplifications in human breast and cervical carcinomas using molecular and cytogenetic methods, especially FISH. READ MORE