Search for dissertations about: "ErbB2"

Showing result 16 - 20 of 26 swedish dissertations containing the word ErbB2.

  2. 16. Genomic profiling and gene-gene interaction in rheumatoid arthritis

    Author : Klementy Shchetynsky; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Complex disease is characterized by the interplay of multiple genetic and environmental factors. Rheumatoid arthritis (RA) is a complex autoimmune disease with a pronounced genetic component, mainly due to HLA-DRB1 gene, but also a multitude of loci outside the HLA region. READ MORE

  4. 17. Canertinib-induced leukemia cell death signaling : effects of a pan-ERBB inhibitor

    Author : Cecilia Trinks; Thomas Walz; Jan-Ingvar Jönsson; Anna-Lotta Hallbeck; Dan Grandér; Linköpings universitet; []
    Keywords : ;

    Abstract : Acute myelogenous leukemia (AML) is the most common acute leukemia affecting adults, the second most frequent leukemia in children, and remains one of the most difficult to cure. Despite a substantial progress in understanding the pathogenesis of AML, general and rather unspecific cytostatic drugs such as cytarabine and anthracyclins still make up the cornerstones of therapy. READ MORE

  5. 18. Investigations of Leucine-rich repeats and immunoglobulin-like domain-proteins 1 and 2 (LRIG1 and LRIG2) and their genes in cancer

    Author : Mahmood Faraz; Håkan Hedman; Roger Henriksson; Rolf Bjerkvig; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LRIG1; LRIG2; PDGFR; glioma; interactome; breast cancer; prognosis; Oncology; onkologi;

    Abstract : The mammalian leucine-rich repeats and immunoglobulin-like domains (LRIG) gene family consists of three different members, LRIG1, LRIG2, and LRIG3. These genes are expressed in all human and mouse tissues analyzed to date. READ MORE

  6. 19. Studies on the effect of ErbB tyrosine kinase inhibitors on malignant melanoma growth and survival in vitro

    Author : Emelie Djerf; Thomas Walz; Anna-Lotta Hallbeck; Olle Stål; Curt Peterson; Johan Hansson; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Malignant melanoma has one of the fastest increasing incidences among the different types of cancerin the Western world. This raise can partly be ascribed to the change in sun habits that has takenplace during the last decades, since the major external risk factor for melanoma is exposure toultraviolet radiation. READ MORE

  7. 20. Novel Roles of the Ack1 Kinase in Epithelial Biology

    Author : Giulia Pilia; Ingvar Ferby; Bengt Hallberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ack1; Epithelial homeostasis; Cell Signalling; Cancer; Apoptosis; TRAIL-R; Yap Taz; Mechanotransduction; ErbB3; Molekylär cellbiologi; Molecular Cellbiology;

    Abstract : Epithelial homeostasis is maintained through integration of diverse signals that regulate cell fate. A strict control of such signals is required to prevent overproliferation and, ultimately, oncogenesis. In this thesis we identify novel roles of Activated Cdc42-associated kinase 1 (Ack1) in maintenance of epithelial homeostasis. READ MORE