Search for dissertations about: "ErbB2"
Showing result 6 - 10 of 26 swedish dissertations containing the word ErbB2.
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6. An albumin-binding domain as a scaffold for bispecific affinity proteins
Abstract : Protein engineering and in vitro selection systems are powerful methods to generate binding proteins. In nature, antibodies are the primary affinity proteins and their usefulness has led to a widespread use both in basic and applied research. READ MORE
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7. Genomic profiling of breast cancer by microarray-based technology and bioinformatics
Abstract : Cancer is a genetic disease that arises when a cell acquires unlimited growth potential through a series of mutational events, which target genes essential for normal cell control and maintenance. Breast cancer is one of the most frequent malignancies in women worldwide, and it is characterized by heterogeneous tumor biology, histological subtypes, variable prognosis and variable responsiveness to treatment. READ MORE
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8. Effects of c-erbB2 signaling on morphogenesis and cell adhesion in mammary epithelial cells
Abstract : .... READ MORE
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9. The mechanism of integrin inactivation and cell signalling induced by c-erbB2, an oncogenic growth factor receptor
Abstract : Overexpression of the oncogenic growth factor receptor, c-erbB2, is linked with poor prognosis in breast carcinomas and is used as a target for therapeutic strategies. To elucidate the mechanism underlying the tumorigenic action of an elevated c-erbB2 level, leading to homodimerization and activation, we have used an inducible system where a hybrid receptor consisting of the cytoplasmic and transmembrane domains of c-erbB2 fused to the extracellular domain of the trkA NGF receptor has been stably transfected into an immortalized mammary epithelial cell line. READ MORE
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10. Molecular factors influencing epithelial-mesenchymal transition in breast cancer
Abstract : Epithelial-mesenchymal transition (EMT) is a developmental process defined by loss of epithelial characteristics and acquisition of mesenchymal phenotype. EMT or similar processes are also implicated in carcinoma cell invasion and the progression of breast carcinoma to metastasis. READ MORE