Search for dissertations about: "ErbB3"

Showing result 11 - 15 of 15 swedish dissertations containing the word ErbB3.

  2. 11. Studies on the effect of ErbB tyrosine kinase inhibitors on malignant melanoma growth and survival in vitro

    Author : Emelie Djerf; Thomas Walz; Anna-Lotta Hallbeck; Olle Stål; Curt Peterson; Johan Hansson; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Malignant melanoma has one of the fastest increasing incidences among the different types of cancerin the Western world. This raise can partly be ascribed to the change in sun habits that has takenplace during the last decades, since the major external risk factor for melanoma is exposure toultraviolet radiation. READ MORE

  4. 12. Staphylococcal surface display in directed evolution

    Author : Nina Kronqvist; Stefan Ståhl; Mats A. A. Persson; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; affibody; combinatorial library; directed evoluation; Gram-positive bacteria. protein engineering; Bioengineering; Bioteknik;

    Abstract : Engineered affinity proteins have together with naturally derived antibodies becomeindispensable tools in many areas of life-science and with the increasing number ofapplications, the need for high-throughput methods for generation of such different affinityproteins is evident. Today, combinatorial protein engineering is the most successful strategy toisolate novel non-immunoglobulin affinity proteins. READ MORE

  5. 13. Canertinib-induced leukemia cell death signaling : effects of a pan-ERBB inhibitor

    Author : Cecilia Trinks; Thomas Walz; Jan-Ingvar Jönsson; Anna-Lotta Hallbeck; Dan Grandér; Linköpings universitet; []
    Keywords : ;

    Abstract : Acute myelogenous leukemia (AML) is the most common acute leukemia affecting adults, the second most frequent leukemia in children, and remains one of the most difficult to cure. Despite a substantial progress in understanding the pathogenesis of AML, general and rather unspecific cytostatic drugs such as cytarabine and anthracyclins still make up the cornerstones of therapy. READ MORE

  6. 14. Studies of LRIG1 and the ERBB receptor family in breast and colorectal cancer

    Author : Ingrid Ljuslinder; Beatrice Malmer; Håkan Hedman; Roger Henriksson; Irina Golovleva; Mef Nilbert; Umeå universitet; []
    Keywords : breast cancer; colorectal cancer; LRIG1; EGFR; ERBB2; invasive margin; onkologi; Oncology;

    Abstract : The LRIG1 gene (leucine-rich repeats and immunoglobulin like domains-1) at chromosome 3p14 is a proposed tumour suppressor gene whose gene product negatively regulates various receptor tyrosine kinases. This function has been the basis for classifying LRIG1 as a potential tumour suppressor gene (TSG). READ MORE

  7. 15. The leukocyte complexity and mutational landscape of periampullary adenocarcinoma. Morphology matters

    Author : Sebastian Lundgren; Tumörmikromiljö; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; periampullary adenocarcinoma; pancreatic cancer; immune microenviroment; prognosis; macrophages; natural killer cells; natural killer T cells; T cells; B cells;

    Abstract : Background: Periampullary adenocarcinomas are a heterogenous group of tumours with poor prognosis that hasnot improved considerably the last decades. Tumour morphology, i.e. intestinal type (I-type) or pancreatobiliarytype (PB-type), has been demonstrated to be a more relevant prognostic factor than anatomical origin. READ MORE