Search for dissertations about: "Excitotoxic"

Showing result 21 - 25 of 35 swedish dissertations containing the word Excitotoxic.

  2. 21. alpha-Melanocyte-stimulating hormone in neurodegenerative processes

    Author : Åsa Forslin Aronsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : alpha-MSH; excitotoxicity; gliosis; ischemia; memory; stereology;

    Abstract : The fact that inflammatory processes accompany the neuronal cell death in most neurodegenerative disorders, has in recent years inspired to studies on the role of inflammation in the brain and the possibility to prevent or stop the degenerative processes by treatment with anti-inflammatory drugs. Neurodegenerative disorders are often accompanied by a progressive loss of memory, and substances that can improve memory functions are of great interest. READ MORE

  4. 22. Somatostatin neurotransmission : studies on experimentally induced cognitive changes and Alzheimer’s disease

    Author : Lars Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Alzheimer s disease Adenylyl cyclase Autoradiography Behavior Cerebral cortex DemenbaEnvironment Ibotenic acid lesion In-situ hybridization Learning Neuropeptides Northern blot Nucleus basalismagnocellularis Posttranslational processing Rat Recepto;

    Abstract : Several neuropeptides are widely distributed in regions of the central nervous system (CNS) which are associated with cognitive functions. Multiple studies on postmortem Alzheimer's disease (AD) brains have shown depleted neuropeptide content and morphological abnormalities of somatostatin (SS)-containing interneurons in the hippocampus and the cerebral cortex. READ MORE

  5. 23. Microglial Glutamate Transporters - Regulation of Expression and Possible Physiological Functions

    Author : Mikael Persson; Göteborgs universitet; []
    Keywords : anaphylatoxin; central nervous system; herpes simplex virus; glutamate transport; glutathione; GLT-1; lipopolysaccharide; microglia; neuroinflammation; oxidative stress; protection; tumour necrosis factor-alpha;

    Abstract : Microglia are considered as the immunocompetent cells of the central nervous system (CNS). Being the first line of defence, they have prominent roles in monitoring the homeostasis and the extracellular milieu and can rapidly and specifically react to any disturbances such as brain trauma, ischemia, neurodegenerative diseases, or infections. READ MORE

  6. 24. Pharmacological and environmental modulations of the rat glutamatergic system

    Author : Josefine Andin; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Glutamate is the principal excitatory neurotransmitter in the central nervous system and it is implicated in neural transmission, learning, memory processes and neuronal plasticity. In the glutamatergic synapse two main components are present; the glutamate receptors and the glutamate transporters. READ MORE

  7. 25. Mitochondrial dysfunction in neurodegeneration

    Author : Mats Ekstrand; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Mitochondria; TFAM; Parkinson s disease; neurodegeneration;

    Abstract : The mitochondrial respiratory chain (RC) is responsible for providing most of the cellular energy in the form of ATP, and is also one of the main sites of reactive oxygen species (ROS) formation. The RC, consisting of five enzyme complexes in the inner mitochondrial membrane, is unique in its bipartite dependence on both nuclear and mitochondrial DNA (mtDNA). READ MORE