Search for dissertations about: "ExoS"

Showing result 1 - 5 of 8 swedish dissertations containing the word ExoS.

  2. 1. Exoenzyme S of Pseudomonas aeruginosa : cellular targets and interaction with 14-3-3

    Author : Lubna Yasmin; Bengt Hallberg; Joan Olson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ExoS; ADP-ribosylation; 14-3-3 protein; Pseudomonas aeruginosa; Small GTPases; RAS; RAP; Pathology; Patologi;

    Abstract : Pseudomonas aeruginosa is an opportunistic pathogen that is a serious problem for immuno-compromised patients. Toxins such as exoenzyme (Exo) S, ExoT, ExoY and ExoU are secreted and translocated from the bacteria into the eukaryotic cell via the bacterial encoded type III secretion system. READ MORE

  4. 2. Cellular targets of Pseudomonas aeruginosa toxin Exoenzyme S

    Author : Maria Henriksson; Bengt Hallberg; Lars Rönnstrand; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Pseudomonas aeruginosa; ADP-ribosylation; GAP; Ras superfamily; NAD; ExoS; 14-3-3; Cellbiologi; Cell biology; Cellbiologi; molecular cell biology; molekylär cellbiologi;

    Abstract : Pseudomonas aeruginosa is an opportunistic pathogen that can cause life-threatening infections in immunocompromised patients. It uses a type III secretion dependent mechanism to translocate toxic effector proteins directly into the eukaryotic cell. READ MORE

  5. 3. Type III Secretion Mediated Translocation of Effector Exoenzymes by Pseudomonas aeruginosa

    Author : Charlotta Sundin; Åke Forsberg; Anthony Pugsley; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Pseudomonas aeruginosa; type III secretion system; ExoS; ExoT; PcrV; PcrG; PopB; PopD; PopN; type IV pili; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : .... READ MORE

  6. 4. Extracellular Vesicles and RNA interference in tumors

    Author : Taral R Lunavat; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melanoma; Therapeutics; Exosome-mimetic nanovesicles; Apoptotic bodies; Microvesicles; Exosomes;

    Abstract : Extracellular vesicles (EVs) including apoptotic bodies (ABs), microvesicles (MVs), exosomes (EXOs) and cell derived artificial nanovesicles (NVs) are important mediators of cell-to-cell communication, in part by transferring bioactive molecules such as DNA, mRNA, miRNA, siRNA, proteins, and lipids. These EVs are released by many cell types, including melanoma cells, and are found in many body fluids. READ MORE

  7. 5. Towards novel antibacterials : Synthesis and identification of natural product inspired inhibitors of Chlamydia trachomatis and development of chemical probes targeting virulence of Pseudomonas aeruginosa

    Author : Michael Saleeb; Mikael Elofsson; Anna Linusson Jonsson; Andreas Kirschning; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Antibacterials; antibiotics; small molecules; natural products; benzofuran; dihydrobenzofuran; the type III secretion system; Pseudomonas aeruginosa; Chlamydia trachomatis; phenotypic screening; high-throughput screening; surface plasmon resonance; drug discovery; bacterial toxins; enzyme inhibitors; organisk kemi; Organic Chemistry;

    Abstract : Antibiotic resistance has evolved significantly to become one of the serious threats to public health today. Yet, the pipeline of new antibiotics is drying up and is lagging behind the challenging needs. READ MORE