Search for dissertations about: "Exosome"
Showing result 1 - 5 of 35 swedish dissertations containing the word Exosome.
-
1. Novel roles of ErbB3 receptor tyrosine kinase in vesicular trafficking
Abstract : ErbB3 is a catalytically impaired receptor tyrosine kinase (RTK) from the EGFR family. Upon ligand binding, ErbB3 forms heterodimers with other members of the family and triggers phosphorylation cascades that promote crucial cellular functions as proliferation, differentiation and survival. READ MORE
-
2. Towards specific quantification of exosomes using surface-based sensing
Abstract : When exosomes were first observed in 1967, they were believed to be cell debris until extensive studies demonstrated key biological functionalities related to their composition and formation mechanism. Exosomes are nanometer-sized lipid vesicles of endocytic origin, with a membrane consisting of lipids and proteins and encapsulating a cargo composed of soluble proteins and genetic material. READ MORE
-
3. Mediator and its role in non-coding RNA and chromatin regualtion
Abstract : Mediator is a multiprotein complex required for the regulation of RNA Polymerase II (Pol II) transcription. Mediator transmits regulatory signals from activators and repressors to the Pol II machinery at the promoter, but the complex has also many other functions related to control of gene transcription. READ MORE
-
4. mRNA degradation factors as regulators of the gene expression in Saccharomyces cerevisiae
Abstract : Messenger RNA degradation is crucial for the regulation of eukaryotic gene expression. It not only modulates the basal mRNA levels but also functions as a quality control system, thereby controlling the availability of mRNA for protein synthesis. READ MORE
-
5. Mechanistic studies on the role of extracellular vesicles in the tumor microenvironment
Abstract : The transition from normal into malignant cells with acquired uncontrolled growth is a process where cancer cells viciously develop adaptive strategies to overcome microenvironmental and metabolic stress. Hypoxia, or deficient oxygen supply, is a common feature of the expanding tumor which alters cell metabolism and consecutively causes lowered intracellular pH. READ MORE