Search for dissertations about: "Extracellulär matrix ECM"

Showing result 1 - 5 of 6 swedish dissertations containing the words Extracellulär matrix ECM.

2. 1. Development of Novel Therapies, Models, and Biomarkers for Osteoclast-Related Diseases

   Author : Henrik Löfvall; Avdelningen för molekylärmedicin och genterapi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Osteopetros; Biomarkör; Cellodling; Extracellulär matrix ECM ; Osteoklast; Osteoclast; Biomarker; Cell culture; Osteopetrosis; Gene Therapy; Extracellular matrix ECM ;

   Abstract : Osteoclasts are derived from hematopoietic stem cells (HSCs) and form upon stimulation of osteoclast precursors by macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor κΒ ligand (RANKL). Osteoclasts resorb bone by secreting hydrochloric acid, matrix metalloproteinases (MMPs) and cathepsin K. READ MORE

4. 2. Cardiac hypertrophy : transcription patterns, hypertrophic progression and extracellular signalling

   Author : Nina Gennebäck; Stellan Mörner; Anders Waldenström; Urban Hellman; Ali J Marian; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiac hypertrophy; HCM; gene expression; OPLS-DA; multivariate dataanalysis; cardiomyocytes; exosomes; microvesicles; Medicine; medicin;

   Abstract : Background: The aim of this thesis was to study transcription patterns and extracellular signalling of the hypertrophic heart to better understand the mechanisms initiating, controlling and maintaining cardiac hypertrophy.Cardiac hypertrophy is a risk factor for cardiovascular morbidity and mortality. READ MORE

5. 3. Decellularized liver extracellular matrix as a 3D scaffold for bioengineering applications

   Author : Vamakshi Khati; Aman Russom; Håkan Jönsson; Giulia Gaudenzi; Ana Teixeira; KTH; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; liver decellularization; decellularized liver matrix bioink; bioprinting; sacrificial scaffold; viscoelasticity; bioengineering; tumor modeling; stem cell differentiation; bioreactor; Biotechnology; Bioteknologi;

   Abstract : The increasing global burden of end-stage liver disease has increased the need for liver transplantation, the definitive cure. However, there is a huge discrepancy between the number of available organ donors and the number of patients waiting for transplantation, resulting in the deaths of a significant number of patients on the waiting list as only 10% of the global need for transplantation is met. READ MORE

6. 4. The role of leucine-rich repeat glycoproteins/proteoglycans in the assembly of collagen matrices

   Author : Liz Svensson; Institutionen för experimentell medicinsk vetenskap; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reumatologi; muskelsystem; Skelett; decorin; Collagen; fibromodulin; extracellular matrix; lumican; collagen fibrillogenesis; Skeleton; rheumatology locomotion; muscle system; Biochemistry; Biokemi; Metabolism;

   Abstract : The properties of different connective tissues depend on the synthesis and assembly of macromolecular structures composed of collagen and other extracellular matrix components. Mechanisms modulating these events play important roles in the formation of a functional tissue. READ MORE

7. 5. Microscopy-based single-cell in vitro assays for NK cell function in 2-D and 3-D

   Author : Per Erik Olofsson; Björn Önfelt; Khakoo Salim; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biological Physics; Biologisk fysik;

   Abstract : Natural killer (NK) cells are effector cells of the innate immune system that are responsible for mediating cellular cytotoxicity against virally infected or neoplastically transformed cells. NK cell subsets are defined by their expression of certain cell-surface markers, and are usually related to activation and developmental status. READ MORE