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Showing result 1 - 5 of 225 swedish dissertations matching the above criteria.
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1. Studies on extracellular matrix proteins in vascular disease
Abstract : The composition of the vascular extracellular matrix (ECM) is altered during remodeling conditions such as atherosclerosis. The changed ECM regulates events that are important for the progression of disease including smooth muscle cell (SMC) behaviour and collagen fiber formation. READ MORE
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2. Proteins of the Inter-α-inhibitor Family : Biosynthesis, Plasma Clearance and Interaction with Extracellular Matrix Components
Abstract : Bikunin, a chondroitin sulfate-containing protein of 25 kDa, has protease inhibitory activity and occurs in the plasma in free and complexed form. In inter-α-inhibitor (IαI) and pre-a-inhibitor (PαI) it is covalently linked through its chondroitin sulfate (CS) chain to two or one other polypeptide of about 80 kDa – heavy chains 1 and 2 (H1, H2) and heavy chain 3 (H3) – respectively. READ MORE
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3. Extracellular Matrix Based Materials for Tissue Engineering
Abstract : The extracellular matrix is (ECM) is a network of large, structural proteins and polysaccharides, important for cellular behavior, tissue development and maintenance. Present thesis describes work exploring ECM as scaffolds for tissue engineering by manipulating cells cultured in vitro or by influencing ECM expression in vivo. READ MORE
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4. Fluid biomarkers of extracellular matrix remodelling across neurological diseases
Abstract : Neurological diseases constitute a major health and socioeconomic issue. Despite an enormous amount of research going on globally, the prevalence and mortality of neurological disorders are still rising. READ MORE
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5. Structure and Interactions of the Extracellular Matrix Protein PRELP
Abstract : This thesis describes the structure and interactions of a novel extracellular matrix protein - PRELP (proline arginine-rich end leucine-rich repeat protein). The amino acid sequence of PRELP showed that it belonged to the leucine-rich repeat (LRR) protein family in connective tissues. READ MORE