Search for dissertations about: "Extracellular matrix proteins"

Showing result 11 - 15 of 225 swedish dissertations containing the words Extracellular matrix proteins.

  2. 11. Immunosuppressive and metastasis-promoting matrisome proteins in pancreatic cancer : the role of galectin 4 and SERPINB5

    Author : Tommy Lidström; Daniel Öhlund; Håkan Hedman; Ola Billing; Andreas Lundqvist; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pancreatic cancer; galectin 4; immunotherapy; SERPINB5; metastasis; extracellular matrix; drug target; Oncology; onkologi; immunologi; Immunology; Medicine; medicin;

    Abstract : In Sweden 1200-1300 people are diagnosed with pancreatic ductal adenocarcinoma (PDAC) every year. Late diagnosis, together with poor treatment response and resistance to checkpoint inhibitor immunotherapy, contributes to the poor prognosis of the disease. READ MORE

  4. 12. Complex Formation in the Extra Cellular Matrix- Structural Study of CTLD of Agrrecan, Tenascin-R and Chondroadherin

    Author : Anna Pramhed; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; aggrecan; ECM; fibulin; structure; tenascin; CHAD; chondroadherin; X-ray; crystallography; calcium; CTLD; C-type lectin; fibronectin; FnIII; LRR; epidermal growth factor; leucine-rich repeat; matrix; EGF; cbEGF;

    Abstract : The cells of higher organisms exist in a complex protein network, the extracellular matrix (ECM), which has a wide variety of different components such as glycoproteins, proteoglycans and carbohydrates. As well as being the physical scaffold on which the cells are dependent for their positioning and mobility, the ECM exercises control over the cells, and changes in the matrix will affect the adhesion, proliferation and differentiation properties of these cells. READ MORE

  5. 13. Proteoglycan Lectin Domain Interactions in Extracellular Matrix Assembly

    Author : Anders Olin; Infektionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicinska vetenskaper allmänt ; General biomedical sciences; crystal structure; network formation; collagen IX; N-glycans; PRELP; cross-linking; fibulin-2; lectin; G3; ECM; proteoglycan;

    Abstract : This thesis focuses on the C-terminal G3 region of the large aggregating proteoglycans that are found in complex with hyaluronan in the extracellular matrix. The G3 region contains a C-type lectin domain that binds different extracellular matrix proteins playing an integral role in tissue organization during development and remodeling. READ MORE

  6. 14. Basement membrane components in the chondrocyte extracellular matrix

    Author : Alexander Kvist; Lunds universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Skelett; rheumatology locomotion; nidogen; chondroitin sulfate; collagen assembly; Skeleton; muscle system; type IV collagen; laminin; perlecan; basement membranes; ECM; chondrcytes; muskelsystem; reumatologi;

    Abstract : The extracellular matrix (ECM) is a network of macromolecules which, together with cells, forms the various tissues of all metazoan organisms. Cartilage, in contrast to most other tissues, contains relatively few cells in proportion to the volume occupied by ECM. READ MORE

  7. 15. Plasma membrane arabinogalactan proteins

    Author : Lars Snogerup; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; arabinogalactan protein plant development cell-cell interaction plasma membrane; Plant biochemistry; Växtbiokemi;

    Abstract : Arabinogalactan proteins (AGPs) are proteoglycans found at the outer side of the plasma membrane and in the extracellular matrix of plants. To be able to study the plasma membrane bound AGPs, a method using SDS-agarose gel electrophoresis (SDS-AGE) was developed to overcome the problems associated with electrophoretic separation of highly glycosylated proteins. READ MORE