Search for dissertations about: "Extracellular matrix"

Showing result 6 - 10 of 448 swedish dissertations containing the words Extracellular matrix.

  1. 6. Towards surgical use of matrix metalloproteinase biology

    University dissertation from Linköping University Electronic Press

    Author : Björn Pasternak; Linköpings universitet.; Linköpings universitet.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Achilles tendon; colon; tetracyclines; tissue inhibitor of metalloproteinases TIMP ; wound healing.; colorectal surgery; extracellular matrix; humans; matrix metalloproteinases MMPs ; rats; surgical anastomosis; sutures; tendon injuries; MEDICINE Surgery Surgical research Orthopaedics; MEDICIN Kirurgi Kirurgisk forskning Ortopedi;

    Abstract : Matrix metalloproteinases (MMPs), such as collagenases, are a family of enzymes capable of degrading most constituents of the extracellular matrix. MMPs are thought to be involved in the aetiopathogenesis of tendon rupture. Additionally, failure of healing has in some instances been associated with elevated levels of MMPs. READ MORE

  2. 7. Remodelling of extracellular matrix in rectal cancer and preoperative radiotherapy

    University dissertation from Linköping University Electronic Press

    Author : Eva Angenete; Göteborgs universitet.; Gothenburg University.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; radiotherapy; rectal cancer; extracellular matrix; MMP-2; PAI-1; uPA; Calprotectin; TGF-beta1;

    Abstract : BACKGROUND Preoperative radiotherapy reduces local recurrence due to rectal cancer, but increases postoperative morbidity. The aim of this thesis was to study the impact of radiotherapy on extracellular matrix (ECM) remodelling enzymes and growth factors after radiotherapy and also their possible use as surrogate markers for complications. READ MORE

  3. 8. Migration on extracellular matrix surface and infiltration into matrix - two distinguishable activities of human T cells

    University dissertation from Linköping University Electronic Press

    Author : Jyrki Ivanoff; Umeå universitet.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; extracellular matrix; fibronectin; collagen type IV; laminin; neuropeptide; chemokine; TIMP-1; MMP-9; T cells; Migration; Immunologi; MEDICINE Microbiology; immunology; infectious diseases Immunology; MEDICIN Mikrobiologi; immunologi; infektionssjukdomar Immunologi; Clinical Immunology; klinisk immunologi;

    Abstract : Migration of T-lymphocytes on a surface coated with extracellular matrix (ECM) components (two-dimensional (2-D) migration) and migration (infiltration) into a matrix (Three-dimesional (3-D) migration) are complex events and the underlying mechanisms are not yet fully understood. Here 2-D and 3-D migration were studied by use of seven leukemic T-cell lines representing discrete differentiation stages, a non-leukemic T-cell clone, and normal peripheral blood T cells. READ MORE

  4. 9. Pancreatic extracellular communication. Applications to beta cell cultures and islet amyloid polypeptide aggregation

    University dissertation from ; Chalmers tekniska högskola; Gothenburg

    Author : Diana Ribeiro; [2018]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; in vitro pancreatic models; induced pluripotent stem cells; stem cell differentiation; insulin; 3D-culture; extracellular vesicles; glucose-stimulated insulin secretion; islet amyloid polypeptide; type 2 diabetes mellitus; extracellular matrix; adipose-derived stem cells; Diabetes mellitus; protein aggregation;

    Abstract : Diabetes mellitus (DM) is a disease with epidemic proportions due to increased incidences worldwide, persistence of undiagnosed cases, uncontrolled forms of the disease, association with cardiovascular complications, and lack of definitive treatment options. In particular, type 2 DM (T2DM) is placing an enormous financial burden on worldwide healthcare systems that will increase in the futureThere is a need to develop physiological assay platforms that provide functionally relevant models of diabetes in order to accelerate the discovery of new treatments. READ MORE

  5. 10. Remodeling of airway epithelium and lung extracellular matrix in COPD and IPF

    University dissertation from Lund University, Faculty of Medicine

    Author : Ulf Hedström; Lunds universitet.; Lund University.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chronic obstructive pulmonary disease; Idiopathic pulmonary fibrosis; Extracellular matrix; Epithelial cells; Remodeling;

    Abstract : .... READ MORE