Search for dissertations about: "Extracellular-signal"

Showing result 1 - 5 of 48 swedish dissertations containing the word Extracellular-signal.

  1. 1. Delayed Cell Death after Traumatic Brain Injury : Role of Reactive Oxygen Species

    Author : Fredrik Clausen; Lars Hillered; Tiit Mathiesen; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Traumatic Brain Injury; Reactive oxygen species; Fluid percussion injury; Controlled cortical impact; weight drop injury; Extracellular-signal regulated kinase; apoptosis; free radical scavenging; morphology; functional outcome; Neurovetenskap; Neurology; Neurologi;

    Abstract : Traumatic brain injury (TBI) is a leading cause of death and disability TBI survivors often suffer from severe disturbances of cognition, memory and emotions. Improving the treatment is of great importance, but as of yet no specific neuroprotective treatment has been found. READ MORE

  2. 2. Inflammatory response and intervention in experimental acute pancreatitis

    Author : Changbin Shi; Lund Kirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kirurgi; ortopedi; traumatologi; traumatology; Surgery; orthopaedics; signalling pathways; protein kinase C; nuclear factor-kB; leukocytes; inflammatory mediators; immunosuppression; acute pancreatitis; extracellular signal-regulated kinase;

    Abstract : Acute pancreatitis (AP) is a common disease where underlying mechanisms for the local initiating events in the pancreas, the systemic dissemination of the inflammatory response and remote organ dysfunction still are unclear. The overall aim of the thesis was to study mechanisms of the inflammatory response in AP with special emphasis on local, systemic, and distant organ injury directed at different signalling pathways, and potential therapeutic strategies to prevent the development of inflammation and cell injury following AP. READ MORE

  3. 3. A Path for Improving Stroke Recovery. Effects of MEK-ERK1/2 Inhibition

    Author : Maryam Mostajeran; Lund Medicin; []
    Keywords : Ischemic stroke; Extracellular-signal regulated kinase ERK 1 2; Mitogen activated protein kinase kinase MEK 1 2; Recovery; Functional outcome; sex;

    Abstract : The present thesis aimed to shed more light on the notion of acute inhibition of extracellular-signal regulated kinase (ERK)1/2 pathway as a treatment to improve stroke recovery. Stroke is a major cause of death and long-term disability worldwide, classified as ischemic or hemorrhagic. READ MORE

  4. 4. Regulation of signal transduction in the striatum by typical and atypical antipsychotic drugs

    Author : Kerstin Håkansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Adenosine A2A receptor; basal ganglia; cAMP-dependent protein kinase; clozapine; DARPP-32; dopamine D 2 receptor; extracellular signal-regulated protein kinases 1 and 2; extrapyramidal side effects; glutamate AMPA receptor; haloperidol; knockout mouse; phosphorylation; schizophrenia; tyrosine hydroxylase.;

    Abstract : The only effective therapy for schizophrenia is based on the use of antipsychotic drugs. These substances act as dopamine D 2 receptor antagonists and can be classified as typical or atypical. Typical antipsychotics, e.g. READ MORE

  5. 5. Importance of MAPK and PKC in cerebrovascular endothelin receptor changes

    Author : Marie Henriksson; Lund Medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; farmakognosi; farmaci; toxikologi; toxicology; pharmacy; pharmacognosy; Pharmacological sciences; Kardiovaskulära systemet; Cardiovascular system; Fysiologi; Physiology; cerebral arteries; ischemia; receptors; endothelin; Farmakologi;

    Abstract : Endothelin is a vasoactive peptide that exerts its effect through two receptors; the endothelin type A (ETA) and type B (ETB) receptor. The contractile ETA receptor is localized on smooth muscle cells in the vascular wall, while the ETB receptors are mainly situated on endothelial cells, mediating vasodilatation. READ MORE