Search for dissertations about: "F-actin"

Showing result 1 - 5 of 47 swedish dissertations containing the word F-actin.

  2. 1. Mechanism of F-actin crosslinking by filamin A and the anti-inflammatory functions of plasma gelsolin in bodily fluids

    Author : Teresia Magnuson Osborn; Göteborgs universitet; []
    Keywords : Cytoskeleton; Crosslinking; F-actin; Filamin; Gelsolin; Inflammation; Plasma; Platelet-activating factor; Lysophosphatidic acid; Rheumatoid arthritis;

    Abstract : Gelsolin (GSN) and filamin A (FLNa) are two actin-binding proteins discovered in our laboratory over 30 years ago. GSN is a calcium-activated actin severing and barbed end capping protein that is expressed as both intracellular and extracellular (plasma gelsolin, pGSN) isoforms. READ MORE

  4. 2. Mechanisms of neutrophil recruitment in septic lung injury

    Author : Karzan Palani; Kirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; sepsis; infection; neutrophil; lung; chemokines; apoptosis; CD44; F-actin; peptides;

    Abstract : Sepsis is one of leading cause of death despite aggressive surgical intervention and antibiotic therapies. Excessive neutrophil recruitment is a major feature in early phase with immune system dysfunction at later phase. Lung is the most vulnerable, critical and sensitive organ during sepsis process. READ MORE

  5. 3. New Roles of Filamins in Cell Signaling, Transcription and Organ Development

    Author : Xianghua Zhou; Göteborgs universitet; []
    Keywords : filamins; cell movement; hypoxia-inducible factor 1; proto-oncogene proteins c-met; mice; knockout; F-actin-binding proteins; integrins; GTB phosphohydrolases; genetic diseases; inborn; vascular endothelial cell growth factor A; Smad2 protein; hepatocyte growth factor; cartilage; osteogenesis; neovascularization; neoplasm metastasis;

    Abstract : Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin networks and link them to cellular membranes. They integrate cell architectural and signaling functions and are essential for cell locomotion and development. READ MORE

  6. 4. Effects of lipophosphoglycan on macrophage actin dynamics

    Author : Katarina Tejle; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Leishmania donovani is a blood-borne tropicial parasite, which infects humans through bites by Phlebotomine sandflies. The parasite survives and multiplies inside macrophages in inner organs, and causes the deadly disease visceral leishmaniasis (Kala-Azar). Lipophosphoglycan (LPG) is the major surface component of Leishmania donovani promastigotes. READ MORE

  7. 5. Leishmania donovani lipophosphoglycan : effects on actin and phagosomal maturation

    Author : Åsa Holm; Maria Fällman; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Leishmania donovani promastigotes survive intracellularly in macrophages by inhibiting phagosomal maturation. This ability is conferred by surface lipophosphoglycan (LPG), which is transferred to the host-cell plasma and phagosomal membranes during phagocytosis. READ MORE