Search for dissertations about: "FAD"

Showing result 11 - 15 of 33 swedish dissertations containing the word FAD.

  2. 11. Cell death and signal transduction pathways in Alzheimer's disease : the role of presenilin 1

    Author : Bogdan O Popescu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Mutated presenilins (PSs) may cause familial Alzheimer's disease (FAD) by altering neuronal signal transduction pathways, by increasing AP production or by triggering a number of proapoptotic mechanisms. The present thesis explores mechanisms by which PSs regulate signal transduction and cell death with relevance to AD. READ MORE

  4. 12. Quinone reduction sites and the role of heme in succinate:quinone reductase. Studies in Bacillus subtilis and Paracoccus denitrificans

    Author : Mikael Matsson; Biologiska institutionen; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; carboxin; cytochrome b; electron transport; heme; quinone; Paracoccus denitrificans; Bacillus subtilis; Succinate:quinone reductase; succinate dehydrogenase; Microbiology; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

    Abstract : Succinate:quinone reductase (SQR) is an enzyme in the respiratory system of aerobic cells. SQR catalyzes two reactions, the oxidation of succinate to fumarate and the reduction of quinone to quinol. These reactions are coupled by electron transfer within the enzyme from the site of succinate oxidation to the site of quinone reduction. READ MORE

  5. 13. The lower and middle Cambrian of Sweden: trilobites, biostratigraphy and intercontinental correlation

    Author : Niklas Axheimer; Berggrundsgeologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Sedimentologi; Paleontologi; Palaeontology; fysisk geografi; Geologi; physical geography; Geology; Sweden; correlation; trilobites; biostratigraphy; Cambrian; Sedimentology;

    Abstract : This thesis is based on studies of Cambrian successions in Sweden, with particular focus on the middle Cambrian biostratigraphy and its correlative relationship to the proposed global agnostoid zonation. The investigated material, mainly trilobites, was collected from both outcrops and drill cores from five provinces in Sweden: Skåne (Scania), Öland, Västergötland, Jämtland and Lapland. READ MORE

  6. 14. Neuronal nicotinic receptor subtypes in normal ageing, Alzheimer's disease and schizophrenia : influences of neuropathological mechanisms as studied in human autopsy brain and transgenic mice

    Author : Amelia Marutle; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Ageing; Alzheimer s disease; P-amyloid; Nicotinic acetylcholine receptor subtypes; Postmortem human brain; Schizophrenia; Transgenic mice;

    Abstract : Neuronal nicotinic acetylcholine receptors (nAChRs) are transmitter-gated ion channel receptors which are widely distributed in the brain. They mediate the effects of several neurotransmitters including ACh, DA, 5-HT and NA and are important for many normal physiological functions in the brain and are also implicated in a number of CNS disorders, such as AD, PD, schizophrenia, Tourette's syndrome and familial epilepsy. READ MORE

  7. 15. Glutathione reductase from erythrocytes : purification, characterization and identification of functional histidine and arginine residues of the enzyme

    Author : Vijayakumar Boggaram; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : This investigation aims at the development of a rapid, simple purification procedure for glutathione reductase and at an exploration of the chemical groups of the enzyme essential for activity.Glutathione reductase from porcine erythrocytes was purified to homogeneity by the use of affinity chromatography on 2’,5’ ADP-Sepharose 4B. READ MORE