Search for dissertations about: "FAD"

Showing result 16 - 20 of 33 swedish dissertations containing the word FAD.

  2. 16. Structural studies on the extracellular flavocytochrome cellobiose dehydrogenase from Phanerochaete chrysosporium

    Author : Martin Hällberg; Andrea Mattevi; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; cellobiose dehydrogenase; flavocytochrome; hydride transfer; radical mechanism; X-ray crystallography; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; Biology; with specialization in structural biology; biologi; med inriktning mot strukturbiologi;

    Abstract : Microorganisms that degrade lignocellulose play an important role in maintaining the global carbon cycle. Under cellulolytic conditions, the fungus Phanerochaete chrysosporium produces an extracellular flavocytochrome, cellobiose dehydrogenase (CDH), with a proposed role in lignocellulose degradation. READ MORE

  4. 17. Mechanistic insights into the biosynthesis of polyketide antibiotics

    Author : Azmiri Sultana; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Anthracyclines are a group of aromatic polyketide compounds with significant medical importance due to their antineoplastic properties. Doxorubicin and daunorubicin members of this family are among the two most commonly used anticancer drugs. However, these compounds exhibit severe side effects like cardiotoxicity and multi-drug resistance. READ MORE

  5. 18. Selenium in mammalian thioredoxin reductase

    Author : Liangwei Zhong; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Thioredoxin reductase (TrxR) is a major enzyme in regulating intracellular redox status. The enzyme from several mammalian tissues has been purified, showing higher molecular weight and a much broader substrate specificity than E. coli TrxR, but the structural basis of these properties remained unknown. READ MORE

  6. 19. A study of b-secretase cleaved Alzheimer amyloid precursor protein

    Author : Kristina Sennvik; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Alzheimer's disease (AD) is characterized by the degeneration and loss of neurons, intracellular neurofibrillary tangles and the accumulation of extracellular senile plaques consisting mainly of beta-amyloid (A-beta). A-beta is generated from the amyloid precursor protein (APP) through sequential cleavage by proteases P- and gamma-secretase. READ MORE

  7. 20. Plants as Factories for Insect Pheromone Production : Deciphering and Reconstructing Sex Pheromone Biosynthetic Pathways of Female Moths

    Author : Yihan Xia; Funktionell zoologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Pheromones biosynthesis; desaturases; elongases; reductases; plant factories;

    Abstract : Compared to other organisms in which the fatty acyl desaturases (FADs) are mostly involved in normal cellular lipid metabolism, moth FADs have evolved extent functions in the biosynthesis of sex pheromones. Female moths releasespecies-specific sex pheromones to attract conspecific males over a long distance for mating. READ MORE