Search for dissertations about: "FAK"

Showing result 1 - 5 of 32 swedish dissertations containing the word FAK.

  1. 1. Structural and Functional Aspects of β1 Integrin Signalling

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Stina Nilsson; Uppsala universitet.; [2006]
    Keywords : Cell and molecular biology; Integrin; Integrin subunit β1; Integrin activation; Threonine; Phosphorylation; Integrin signalling; FAK; PI3K; MAPK; Cell- och molekylärbiologi;

    Abstract : Integrins are transmembrane glycoproteins primarily mediating interactions of cells with the extracellular matrix. Each receptor is a complex of one α- and one β-subunit with affinity for a diverse set of ligands. READ MORE

  2. 2. The Role of Shb in Angiogenesis, FGF and VEGF Signalling in Endothelial Cells

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Kristina Holmqvist; Uppsala universitet.; [2004]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Shb; Src; FAK; Angiogenesis; VEGFR-2; FGFR-1; Endothelial cells; Spreading; Stress fiber formation; siRNA; VEGF; FGF; Differentiation; Migration; Tube formation; RNAi; Medicin; MEDICINE Dermatology and venerology; clinical genetics; internal medicine; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin;

    Abstract : Angiogenesis is defined as the formation of new capillary blood vessels from pre-existing ones. This process involves several steps including: migration, proliferation and differentiation of endothelial cells into blood vessels. READ MORE

  3. 3. Signal Transduction by Proline-Rich Tyrosine Kinase Pyk2

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Inga Dikic; Uppsala universitet.; [2002]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Onkologi; Protein phosphorylation; tyrosine kinase; Pyk2 FAK; neuronal differentiation; Ras MAP kinase pathway; MEDICINE Surgery Oncology; MEDICIN Kirurgi Onkologi; molekylär cellbiologi; Molecular Cellbiology;

    Abstract : The proline-rich tyrosine kinase (Pyk2) together with focal adhesion kinase (FAK) define a family of non-receptor protein tyrosine kinases that are regulated by diverse stimuli. Activation of Pyk2 has been implicated in multiple signaling events, including modulation of ion channels, activation of MAP kinase cascades and apoptotic cell death. READ MORE

  4. 4. Detecting novel effects of exercise or AMPK activation in human skeletal muscle

    University dissertation from Stockholm : Karolinska Institutet, Dept of Molecular Medicine and Surgery

    Author : David Gray Lassiter; Karolinska Institutet.; Karolinska Institutet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Cardiovascular and metabolic disorders are among the main causes of death today. Regular exercise can prevent and treat these chronic diseases. A molecule at the center of exercise adaptations in skeletal muscle is adenosine monophosphate-activated protein kinase (AMPK). READ MORE

  5. 5. Adhesion-dependent mechanisms regulating mitosis

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Deepesh Kumar Gupta; Uppsala universitet.; [2019]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Cytokinesis; Centrosome; Septin; Abscission; Mitosis; Integrin; Adhesion; Binucleation; Biokemi; Biochemistry;

    Abstract : Integrin-mediated cell adhesion is required for normal cell cycle progression during G1-S transition and for the completion of cytokinesis. Cancer cells have ability to grow anchorage-independently, but the underlying mechanisms and the functional significance for cancer development are unclear. READ MORE