Search for dissertations about: "FAK"

Showing result 11 - 15 of 38 swedish dissertations containing the word FAK.

  2. 11. Molecular mechanisms of imatinib resistance in gastrointestinal stromal tumor with focus on microRNAs

    Author : Pınar Akçakaya; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Gastrointestinal stromal tumor (GIST) is mainly initialized by mutations in receptor tyrosine kinase genes KIT or PDGFRA. The development of imatinib, a small molecule inhibitor that targets these tyrosine kinase receptors, remarkably improved patient outcome. READ MORE

  4. 12. MicroRNA and energy metabolism in gastrointestinal tumors

    Author : Wen-Kuan Huang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : MicroRNAs (miRNAs) contribute to cancer development and drug resistance via cellular biological processes, including metabolic pathways. Energy metabolism plays a significant role to maintain tumor proliferation in gastrointestinal (GI) cancers. However, the roles of miRNAs and energy metabolism in GI cancers are not fully understood. READ MORE

  5. 13. Functional Studies of Collagen-Binding Integrins α2β1 and α11β1 : Interplay between Integrins and Platelet-Derived Growth Factor Receptors

    Author : Gunilla Grundström; Kristofer Rubin; Karl-Eric Magnusson; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

    Abstract : Integrins are heterodimeric cell surface receptors, composed of an α- and a β-subunit, which mediate cell-extracellular matrix (ECM) interactions. Integrins mediate intracellular signals in response to extracellular stimuli, and cooperate with growth factor and other cytokine receptors. READ MORE

  6. 14. The many faces of IGF-1R from cell surface to the nucleus

    Author : Sandra Andersson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The IGF-1R is due to its implication in cancer an intensively studied subject of research. It is well known today that intracellular signals mediated by the IGF-1R play pivotal roles in tumorigenesis and cancer progression. READ MORE

  7. 15. Role of DARPP-32 in Breast Cancer Cell Signalling and Migration

    Author : Christian Hansen; Molekylär neurobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cell migration; protein phosphatase 1.; DARPP-32; breast cancer; protein kinase A;

    Abstract : Breast cancer is the most common form of cancer in women. While the prognosis for breast cancer patients without local or distal dissemination is relatively favorable, the prognosis is considerably worse once distal metastasis has been established. READ MORE