Search for dissertations about: "FAK"

Showing result 16 - 20 of 38 swedish dissertations containing the word FAK.

2. 16. CCN2 – Keratinocyte Interactions In Vitro and In Vivo

   Author : Elizabeth Kiwanuka; Bengt Gerdin; Kristofer Rubin; Filip Farnebo; Uppsala universitet; []
   Keywords : CCN2; connective tissue growth factor; keratinocytes; re-epithelialization; cell migration; cell signaling; Plastikkirurgi; Plastic Surgery;

   Abstract : Cutaneous wound healing is a complex process involving the migration of inflammatory cells to the wound site, deposition of extracellular matrix, and the reestablishment of an intact epithelial barrier. Re-epithelialization depends on the proliferation and directional migration of keratinocytes from the wound edges. READ MORE

4. 17. Adhesion Dependent Signals : Cell Survival, Receptor Crosstalk and Mechanostimulation

   Author : Anjum Riaz; Staffan Johansson; Bengt Hallberg; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Integrins; Signal transduction; Protein kinase B; Akt; PI3K; Heparanase; ROS; Mechanosignalling; Molekylär cellbiologi; Molecular Cellbiology; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi; Cellforskning; Cell Research;

   Abstract : The integrin family of cell surface receptors is evolutionary conserved and found in all multicellular animals. In humans 8-alpha and 18-beta integrins are non-covalently associated into 24 dimers. Integrins mediate cell-extracellular matrix and cell-cell interactions and participate in cell signalling. READ MORE

5. 18. Protein tyrosine kinases and the regulation of signalling and adhesion in drosophila melanogaster

   Author : Caroline Grabbe; Ruth Palmer; Tapio Heino; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Drosophila; Signalling; Adhesion; Protein Tyrosine Kinase; Development; Endocytosis; Molecular biology; Molekylärbiologi;

   Abstract : In order to build a multi-cellular organism and to regulate cellular functions, cells need to communicate with each other, as well as tightly regulate their behaviour in response to environmental changes. For these purposes all eukaryotic cells express a large number of membrane spanning receptors that either themselves contain catalytic activity or via cytoplasmic effector enzymes, function to transmit “signals” from the cell exterior to induce appropriate responses within the cell. READ MORE

6. 19. Prognostic Biomarkers and Target Proteins for Treatment of High-grade Gliomas

   Author : Linda Sooman; Simon Ekman; Johan Lennartsson; Joachim Gullbo; Michael Bergqvist; Erik Blomquist; Stefan Bergström; Beatrice Melin; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; High-grade glioma; prognostic biomarkers; combination chemotherapy; DNA methylation; FGF2; p38 MAPK; PTPN6; camptothecin; imatinib; vandetanib; EGFR; RAC1; Notch; Medical Science; Medicinsk vetenskap; Oncology; Onkologi;

   Abstract : The survival for high-grade glioma patients is poor and the treatment may cause severe side effects. A common obstacle in the treatment is chemoresistance. To improve the quality of life and prolong survival for these patients prognostic biomarkers and new approaches for chemotherapy are needed. READ MORE

7. 20. Mechanisms of Integrin Signal Transduction

   Author : Anne Stefansson; Staffan Johansson; Annika Armulik; Björn Öbrink; Uppsala universitet; []
   Keywords : Cell biology; Integrin; Integrin signalling; PI3K; Akt PKB; Integrin transmembrane domain; cell spreading; Cellbiologi;

   Abstract : Integrins are a protein family of cell surface receptors, expressed in all cell types in the human body, except the red blood cells. Besides their importance in mediating physical connections with the surrounding environment, the integrin family members are also vital signalling mediators. READ MORE