Search for dissertations about: "FARMACI Övrig farmaci"

Found 3 swedish dissertations containing the words FARMACI Övrig farmaci.

  1. 1. Development of Methods for Assessing Unbound Drug Exposure in the Brain In vivo, in vitro and in silico

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Markus Fridén; Uppsala universitet.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood-brain barrier; Drug transport; Tissue distribution; Transporters; Pharmacokinetics; PHARMACY Other pharmacy; FARMACI Övrig farmaci; PHARMACY Biopharmacy; FARMACI Biofarmaci; PHARMACY Pharmaceutical pharmacology; FARMACI Farmaceutisk farmakologi; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Abstract : The blood-brain barrier is formed by tightly joined capillary cells with transporter proteins and acts as to regulate the brain concentration of nutrients as well as many drugs. When developing central nervous system drugs it is necessary to measure the unbound drug concentration in the brain, i.e. the unbound brain exposure. READ MORE

  2. 2. Application of Mixed-Effect Modeling to Improve Mechanistic Understanding and Predictability of Oral Absorption

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Martin Bergstrand; Uppsala universitet.; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Absorption; magnetic marker monitoring; drug release; IVIVC; pharmacometrics; NONMEM; model diagnostics; pcVPC; pvcVPC; visual predictive check; VPC; BQL; paracetamol; sulfapyridine.; PHARMACY Other pharmacy; FARMACI Övrig farmaci; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Abstract : Several sophisticated techniques to study in vivo GI transit and regional absorption of pharmaceuticals are available and increasingly used. Examples of such methods are Magnetic Marker Monitoring (MMM) and local drug administration with remotely operated capsules. READ MORE

  3. 3. Following the mevalonate pathway to bone heal alley

    University dissertation from Acta Orthopaedica, Volume 78, No. 328

    Author : Björn Skoglund; Linköpings universitet.; Linköpings universitet.; Östergötlands Läns Landsting.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Bone screws; coated materials; biocompatible; chemistry; diphosphonates; pharmacology; Equipment failure analysis methods; Femoral fractures; drug therapy; fracture fixation; instrumentation; Fracture fixation; fracture healing; drug effects; simvastatin; tibial fractures; physiopathologyial fractures; surgery; PHARMACY Pharmaceutical chemistry; FARMACI Farmaceutisk kemi; VETERINARY MEDICINE Other veterinary medicine; VETERINÄRMEDICIN Övrig veterinärmedicin;

    Abstract : The mevalonate pathway is an important biosynthetic pathway, found in all cells of virtually all known pro- as well as eukaryotic organisms. This thesis is an investigation into the use of two drugs, originally developed for different applications, but both affecting the mevalonate pathway, in to models of fracture repair. READ MORE