Search for dissertations about: "FARMACI Farmaceutisk kemi"

Showing result 1 - 5 of 78 swedish dissertations containing the words FARMACI Farmaceutisk kemi.

  1. 1. Drugs and polymers in dissolving solid dispersions NMR imaging and spectroscopy

    University dissertation from Stockholm : KTH

    Author : Carina Dahlberg; KTH.; [2010]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURAL SCIENCES Chemistry Physical chemistry; NATURVETENSKAP Kemi Fysikalisk kemi; NATURAL SCIENCES Chemistry Physical chemistry Surface and colloid chemistry; NATURVETENSKAP Kemi Fysikalisk kemi Yt- och kolloidkemi; PHARMACY; FARMACI;

    Abstract : The number of poorly water-soluble drug substances in the pharmaceutical pipeline is increasing, and thereby also the need to design effective drug delivery systems providing high bioavailability. One favourable formulation approach is preparation of solid dispersions, where dispersing a poorly water-soluble drug in a water-soluble polymer matrix improves the dissolution behaviour and the bioavailability of the drug. READ MORE

  2. 2. Phase Phenomena in Polymer Networks Empirical Studies on the Influence of Hydrophobicity, Charge Density and Crosslinks on Macroion-Induced Phase Transitions in Polyelectrolyte Gels

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Martin Andersson; Uppsala universitet.; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Gel; microgel; microsphere; polystyrenesulfonate; polyacrylate; polyacrylicacid; DoTAB; DoTAC; CTAB; CTAC; network; polyelectrolyte; complex salt; self assembly; phase behaviour; hysteresis; thermodynamic; core-shell; lysozyme; cytochrome c; microscopy; micromanipulator; elastomer; elastic; protein; surfactant; phase behaviour; sorting; PHARMACY; FARMACI; NATURAL SCIENCES Chemistry Physical chemistry; NATURVETENSKAP Kemi Fysikalisk kemi;

    Abstract : The thesis concerns polyelectrolyte gels in contact with oppositely charged proteins and surfactant micelles, and includes of four papers (I-IV). In paper I confocal Raman spectroscopy was introduced as a method to trace micelles and investigate the structure of gel-surfactant complexes, in phase separated gel spheres. READ MORE

  3. 3. Microgels as Carriers for Antimicrobial Peptides Surface-bound microgels, and factors affecting peptide interactions

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Lina Nyström; Uppsala universitet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Antimicrobial peptides; Biomaterial coating; Drug delivery; Host defence peptides; Microgels; pH-responsive; Surface-bound; Pharmaceutical Physical Chemistry; Farmaceutisk fysikalisk kemi;

    Abstract : With a growing number of multi-resistant bacteria against conventional antibiotics, there is an urgent need to identify new antimicrobial therapeutics. One example that has gained considerable interest is antimicrobial peptides (AMPs). READ MORE

  4. 4. Microgel Interactions with Peptides and Proteins Consequence of Peptide and Microgel Properties

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Ronja Widenbring; Uppsala universitet.; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Binding; Degradation; Enzyme; Gel; Hydrogel; Microgel; Peptide; Protein; Release; Pharmaceutical Physical Chemistry; Farmaceutisk fysikalisk kemi;

    Abstract : Microgels are lightly cross-linked hydrogel particles in the sub-micrometer to micrometer size range with a capacity to drastically change their volume in response to changes in the external environment. Microgels have an ability to bind and store substances such as biomacromolecular drugs, notably proteins and peptides, and release them upon stimuli, making them potential candidates as drug delivery vehicles and functional biomaterials. READ MORE

  5. 5. On the phase behaviour of hydrogels A theory of macroion-induced core/shell equilibrium

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Jonas Gernandt; Uppsala universitet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; polymer; polyelectrolyte; surfactant; thermodynamics; elasticity; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : Colloidal macroions are known to interact very strongly with oppositely charged polyionic hydrogels. Sometimes this results in a non-uniform distribution of the macroions within the gel, a phenomenon that is not fully understood. READ MORE