Search for dissertations about: "FBW7"

Found 4 swedish dissertations containing the word FBW7.

  2. 1. Mechanisms of Medulloblastoma Dissemination and Novel Targeted Therapies

    Author : Sara Bolin; Fredrik Swartling; Martine F. Roussel; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medulloblastoma; Recurrence; MYC; SOX9; FBW7; Treatment; BET bromodomains; Cyclin-dependent kinases; Oncology; Onkologi;

    Abstract : Medulloblastomas are the most frequent malignant childhood brain tumors, arising in the posterior fossa of children. The overall 5-year survival is 70%, although children often suffer severe long-term side effects from standard medical care. READ MORE

  4. 2. The role of the tumor suppressor gene, FBW7, and mechanisms of its inactivation in cancer

    Author : Shahab Akhoondi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The F-box protein FBW7 is a tumor suppressor and SCF ubiquitin ligase targeting several key oncoproteins for proteasomal degradation. In this thesis we addressed whether the FBW7 gene is inactivated by mutations in various human tumor types and explored alternative mechanism(s) for the inactivation of FBW7. READ MORE

  5. 3. Characterization of F-box proteins and their target substrates in cancer

    Author : Hwee-Fang Ng; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Protein degradation, by means of ubiquitylation tagging for subsequent degradation by the ubiquitin-proteasome system (UPS), has opened up a newfound way of protein degradation some three to four decades back. Termed the ‘kiss of death’, this field of study has since sparked off the quest for substrates for the main enzymes executing ubiquitylation, the E3 ligases. READ MORE

  6. 4. The Role of SOX9 in Medulloblastoma

    Author : Vasil Savov; Fredrik Swartling; Ulrich Schüller; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medulloblastoma; SOX9; MYCN; cancer development; recurrence; regulation; tumor metastasis; migration; Medical Science; Medicinsk vetenskap;

    Abstract : Medulloblastoma (MB) is the most common malignant pediatric brain tumor. Overall survival is about 70% and in cases where current treatment fails, the disease recurs and most often is fatal. At the molecular level, MB can be divided into four defined subgroups: WNT, SHH, Group 3 and Group 4. READ MORE