Search for dissertations about: "FDA"

Showing result 1 - 5 of 58 swedish dissertations containing the word FDA.

  2. 1. Structural and functional studies of enzymes in nucleotide metabolism : a detailed investigation of two enzymes and interaction profiling of FDA-approved nucleoside analog drugs with 23 enzymes

    Author : Louise Egeblad; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Enzymes in nucleotide metabolism serve as the producers of the building blocks for DNA and RNA. From a medical perspective, nucleotide metabolism, and in particular salvage pathway enzymes, have attracted special interest, as nucleoside prodrugs given in the treatment of cancer and HIV are converted into their active metabolite forms by these enzymes. READ MORE

  4. 2. A Model Based Approach to Robustness Analysis and Optimisation of Chromatography Processes

    Author : Niklas Jakobsson; Avdelningen för kemiteknik; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Kemiteknik och kemisk teknologi; Chemical technology and engineering; Langmuir; SMA; Optimisation; Robustness; Chromatography; Prepartive process scale; Modelling;

    Abstract : One of the major issues in the pharmaceutical industry today is the cost of development and validation of the production of the active pharmaceutical ingredients. The development, optimization and validation of a production plant have been dominated by an extensive experimental approach. READ MORE

  5. 3. Process Analytical Tools for the Monitoring and Characterization of Bacterial Toxins

    Author : Martin Hedström; Bioteknik; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Bioteknik; Biotechnology; protein degradation; mass spectrometry; Bacterial toxins; Biosensor;

    Abstract : In the era of proteomics, glycomics and ultimately metabolomics, with constantly increasing knowledge regarding the human biosystem, the number of specialized therapeutic agents which will be developed against different diseases is predicted to be on the upswing. An increasing portion of these new drugs will, according to recent predictions (Labrou, 2003), be of proteinaceous origin produced according to biotechnological standards. READ MORE

  6. 4. Advancement of sensor technology for monitoring and control of upstream bioprocesses

    Author : Judit Randek; Carl-Fredrik Mandenius; Gerald Striedner; Linköpings universitet; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

    Abstract : In bioprocesses, the upstream process part with cultivation and harvesting steps has decisive influence on the final process outcome, including the quality of the product, the productivity and the yield. To ensure stable product quality of biopharmaceuticals, the U.S. READ MORE

  7. 5. Genetic determinants of lung cancer and their application toward therapeutics. The role of ZFP148 transcription factor and anaplastic lymphoma kinase (ALK) fusion proteins in non-small cell lung cancer

    Author : Abdulmalik Bokhari; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Zfp148; TP53; ALK; EML4-ALK; brigatinib; lorlatinib; RRM2; alectinib;

    Abstract : Lung cancer causes severe morbidity and mortality in millions of patients globally each year. Anaplastic lymphoma kinase (ALK) mutations facilitate neoplastic growth of lung cancer in adults and neuroblastoma in pediatric patients. READ MORE