Search for dissertations about: "FGF-23"
Showing result 1 - 5 of 9 swedish dissertations containing the word FGF-23.
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1. The Role of Fibroblast Growth Factor 23 in Phosphate Homeostasis
Abstract : The regulation of serum phosphate (Pi) concentrations is a complex process and our current models are far from complete. Due to major advancements in biotechnology and the development of more powerful research tools, recent advances in the field of genetics has led to the identification of several candidates for the long sought-after phosphatonin(s), or Pi regulating hormones. READ MORE
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2. Fibroblast growth factor-23 and Klotho in bone/mineral and parathyroid disorders
Abstract : Fibroblast growth factor-23 (FGF23) is a novel, bone-produced hormone that regulates renal phosphate (Pi) reabsorption and calcitriol metabolism. Disorders of mineral and bone metabolism, such as autosomal dominant hypophosphatemic rickets (ADHR) and hyperostosis-hyperphosphatemia syndrome (HHS), witness the importance of well-balanced serum levels of FGF23. READ MORE
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3. FGF23 - a possible Phosphatonin
Abstract : Human physiology is dependent on an accurate phosphate (Pi) homeostasis. Defective Pi regulation causes hyper- or hypophosphatemia, which are associated with ectopic calcification or impaired bone mineralization, and a shortened life span. Current endocrine models of Pi homeostasis are incomplete. READ MORE
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4. The role of fibroblast growth factor-23 in chronic kidney disease-mineral and bone disorder
Abstract : Fibroblast growth factor-23 (FGF23) was initially identified as the causative factor of autosomal dominant hypophosphatemic rickets. Further studies confirmed that FGF23 is predominantly expressed in the osteocytes and osteoblasts of bone and that circulating FGF23 acts on the kidney to inhibit renal phosphate reabsorption and 1,25(OH)2D3 hydroxylation. READ MORE
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5. Studies on the phenotype and function of osteoclasts using osteopetrotic and rachitic animal models
Abstract : Osteoclasts are multinucleated bone-resorbing cells that have been implicated in a variety of skeletal diseases e.g. osteoporosis, rheumatoid arthritis and skeletal metastasis. Under physiological conditions, the osteoclast participates in ossification during longitudinal bone growth as well as in bone remodelling during adulthood. READ MORE