Search for dissertations about: "FGF2"

Showing result 16 - 20 of 28 swedish dissertations containing the word FGF2.

  2. 16. Interplay Between Cell of Origin and Oncogenic Activation in Glioma

    Author : Yiwen Jiang; Lene Uhrbom; Anders Persson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioma; PDGF; cell of origin; Sox5; glioma initiating cells; Oncology; Onkologi;

    Abstract : Glioma is the most frequent primary tumor of the central nervous system. By using the RCAS/tv-a mouse glioma model, we have studied mechanisms controlling glioma development and the effect of cell of origin on these processes.SOX5 was identified as a brain tumor locus in a retroviral insertional mutagenesis screen of PDGF-B induced mouse gliomas. READ MORE

  4. 17. Regulation of postnatal neurogenesis and brain angiogenesis by thyroid hormone

    Author : Jenny Liqun Zhang; Göteborgs universitet; []
    Keywords : thyroid hormone; neurogenesis; angiogenesis; SVZ OB; hippocampus; neural stem cells; endothelial cells; astrocytes;

    Abstract : Thyroid hormone (TH), which is secreted by the thyroid gland, exerts significant effects on the central nervous system (CNS), especially during development, so that delayed treatment of perinatal hypothyroidism results in severe cognitive retardation. Continuous postnatal neurogenesis occurs throughout adulthood in the subventricular zone (SVZ) of the lateral ventricle wall and in the subgranular zone (SGZ) of the dentate gyrus (DG) of the hippocampal formation. READ MORE

  5. 18. Galactosaminoglycans - Role in Brittlestar Limb Regeneration

    Author : Rashmi Ramachandra; Dorothe Spillmann; Barbara Mulloy; Uppsala universitet; []
    Keywords : Chondroitin sulfate; Dermatan sulfate; Brittlestar; Regeneration;

    Abstract : Regeneration is, in simple terms, ‘to re-grow’ damaged or lost parts of the body (e.g. cells, tissues and organs) and is a natural phenomenon occurring throughout the life of an organism. The regenerative capacity varies in the animal kingdom. READ MORE

  6. 19. Investigations of Proneural Glioblastoma to Identify Novel Therapeutic Targets

    Author : Maria Boije; Lene Uhrbom; Bengt Westermark; Rolf Bjerkvig; Uppsala universitet; []
    Keywords : Glioma; proneural subtype; hallmarks; glioma initiating cells; S-SOX5; angiogenesis; stromal cells; Tumour biology; Tumörbiologi; Experimentell patologi; Experimental Pathology;

    Abstract : Malignant glioma is a highly lethal and destructive disease with no proper cure. We have investigated some of the hallmarks of cancer in connection to glioma and found ways to disrupt these and prevent tumor growth. The work is done within the context of a glioma subtype distinguished by activation of PDGF signaling termed the proneural subtype. READ MORE

  7. 20. Syndecan - Regulation and Function of its Glycosaminoglycan Chains

    Author : Anna S. Eriksson; Dorothe Spillmann; Catherine Merry; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; heparan sulfate; chondroitin sulfate; integrin; cell motility; fibroblast growth factor signaling; pharyngeal cartilage; biosynthesis regulation; Medical Science; Medicinsk vetenskap;

    Abstract : The cell surface is an active area where extracellular molecules meet their receptors and affect the cellular fate by inducing for example cell proliferation and adhesion. Syndecans and integrins are two transmembrane molecules that have been suggested to fine-tune these activities, possibly in cooperation. Syndecans are proteoglycans, i.e. READ MORE