Search for dissertations about: "FLT3"

Showing result 1 - 5 of 42 swedish dissertations containing the word FLT3.

  1. 1. FLT3 receptor in normal and malignant hematopoiesis

    University dissertation from Lund Stem Cell Center, Faculty of Medicine, LU

    Author : Shabnam Kharazi; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; FLT3-ITD; FLT3; lineage commitment; acute myeloid leukemia; myeloprolifetaive disease; hematopoietic stem cell;

    Abstract : All hematopoietic cells originate from hematopoietic stem cells (HSCs) residing in the bone marrow (BM). The classical model of hematopoietic lineage commitment, that has been the prevailing model for hematopoiesis, proposes that the first lineage commitment step of HSCs and progenitors results in a strict separation of myelopoiesis and lymphopoiesis. READ MORE

  2. 2. Regulation of Apoptosis in Hematopoietic Progenitor Cells: Involvement of Different Signaling Pathways

    University dissertation from Department of Laboratory Medicine, Lund University

    Author : Maria Kraft; [2004]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytokines; apoptosis; cell cycle; c-Kit; Flt3; Flt3-ITD; Akt; Bcl-2; FoxO3; mouse; hematopoiesis; progenitor;

    Abstract : Proliferation, differentiation, and survival of hematopoietic stem cells and multipotent progenitor cells are regulated by cytokines and cell-cell interactions. Kit ligand (KL) and Flt3 ligand (FL) have pleiotropic effects, promotes survival, but are nonredundant. READ MORE

  3. 3. Studies on signaling pathways induced by FLT3, an important oncogene in AML

    University dissertation from Department of Laboratory Medicine, Lund University

    Author : Elena Razumovskaya; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; FLT3; AML; RTK; oncogene; ERK5; hematopoiesis;

    Abstract : FLT3, a receptor tyrosine kinase, is expressed in hematopoietic progenitor cells. FLT3-ITD (internal tandem duplication) and D835 mutations are found in approximately 30% and 7% of Acute Myeloid Leukemia (AML) patients respectively, and correlate with a poor prognosis, thus making the mutated receptor a potential therapeutic target. READ MORE

  4. 4. Expression and role of the cytokine tyrosine kinase receptor flt3 in early hematopoiesis

    University dissertation from Jörgen Adolfsson, Stem Cell Laboratory, BMC B10, Klinikg 26, 22184 Lund

    Author : Jörgen Adolfsson; [2004]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematologi; extracellulära vätskor; extracellular fluids; Haematology; flt3; cytokine; Hematopoiesis; stem cells;

    Abstract : Mature blood cells are crucial for life, but they have a short lifetime and thus have to be replaced. These mature blood cells are produced by lineage restricted progenitors, which themselves are generated by rare multipotent hematopoietic stem cells (HSCs) in a highly dynamic process called hematopoiesis. READ MORE

  5. 5. Translational studies on acute myeloid leukemia focus on the receptor tyrosine kinase FLT3

    University dissertation from Lund University: Faculty of Medicine

    Author : Alissa Marhäll; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; AML; FLT3;

    Abstract : Among adults, acute myeloid leukemia (AML) is the second most frequent type of leukemia. In spite of recent improvements in the treatment of this disease, a majority of patients develop drug resistance, leading to poor overall survival. One of the factors behind this is mutations in the tyrosine kinase receptor (FLT3). READ MORE