Search for dissertations about: "FN"

Showing result 6 - 10 of 76 swedish dissertations containing the word FN.

  2. 6. Functional and structural characterization of integrins and their ligands ICAM-2, vitronectin and fibronectin in leukocytes

    Author : Rosalba Salcedo Amaya; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Leukocytes; Adhesion molecules; Integrins; ICAM-2; Vitronectin; Fibronectin.;

    Abstract : Transient adhesion of leukocytes to cells and extracellular matrices is a crucial process in leukocyte physiology. Cell surface adhesion molecules such as integrins and members of the immunoglobulin (Ig) superfamily are involved. READ MORE

  4. 7. Hierarchical Assembly Investigations and Multiscale Characterization of Protein-based Materials : Insights from Whey Protein Nanofibrils and Recombinant Spider Silk Microspheres

    Author : Eirini Ornithopoulou; My Hedhammar; Thomas Crouzier; Christina Divne; Tim Melander Bowden; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hierarchical Assembly; Protein-based materials; Whey Protein Nanofibrils; β-Lactoglobulin; Recombinant Spider Silk; Microspheres; Biomedical Applications; Surface Biofunctionalization; Hierarkisk montering; Proteinbaserade material; Vassleprotein nanofibriller; β-Laktoglobulin; Rekombinant spindelsilke Mikrosfärer; Biomedicinska tillämpningar; Ytbiokonjugering; Biotechnology; Bioteknologi;

    Abstract : Protein-based materials, with their unique properties of combining high strength, while maintaining elasticity, and their inherent biocompatibility, hold immense potential for various applications. In order to harness these properties, we need to understand and control how protein building blocks come together to form hierarchically structured materials. READ MORE

  5. 8. Pharmacometric Models for Biomarkers, Side Effects and Efficacy in Anticancer Drug Therapy

    Author : Emma K. Hansson; Lena Friberg; Mats O Karlsson; Charlotte Kloft; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacokinetics; Pharmacodynamics; Oncology; Febrile Neutropenia; GIST; Sunitinib; PHARMACY; FARMACI; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Abstract : New approaches quantifying the effect of treatment are needed in oncology to improve the drug development process and to enable treatment optimization for existing therapies. This thesis focuses on the development of pharmacometric models for biomarkers, side effects and efficacy in order to identify predictors of clinical response in anti-cancer drug therapy. READ MORE

  6. 9. Pharmacometric Evaluation of Biomarkers to Improve Treatment in Oncology

    Author : Ida Netterberg; Lena Friberg; Mats Karlsson; Elisabet I. Nielsen; Henrik Lindman; Amit Roy; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; Biomarkers; Oncology; Population PKPD Modeling; NONMEM; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Cancer is a family of many different diseases with substantial heterogeneity also within the same cancer type. In the era of personalized medicine, it is desirable to identify an early response to treatment (i.e., a biomarker) that can predict the long-term outcome with respect to both safety and efficacy. READ MORE

  7. 10. Studies on fibronectin binding proteins, proteases, and virulence in Staphylococcus aureus

    Author : Patricia Saravia Otten; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Staphylococcus aureus produces several surface proteins, many of which bind specifically to different host extracellular matrix (ECM) proteins and plasma proteins, such as fibronectin, collagen and fibrinogen. Two highly homologous fibronectin binding proteins (FnBPA and FnBPB), enconded by fnbA and fnbB, have been characterized. READ MORE