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Showing result 1 - 5 of 19 swedish dissertations matching the above criteria.

  2. 1. Molecular analysis of the FET family fusion oncoprotein FUS-DDIT3

    Author : Christer Thomsen; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; FUS-DDIT3; FUS; EWS; TAF15; DDIT3; myxoid liposarcoma; plectin; SWI SNF;

    Abstract : Chromosomal translocations leading to formation of tumor type specific fusion oncogenes are frequently found in human cancers. The FET family genes (FUS, EWSR1 and TAF15) occur in translocations with genes encoding various transcription factors in sarcomas and leukemias. READ MORE

  4. 2. Functional characterization of the liopsarcoma-associated fusion oncigene FUS-DDIT3

    Author : Melker Göransson; Göteborgs universitet; []
    Keywords : Myxoid round cell liposarcoma; fusion oncogenes; FUS; DDIT3; tumor development; cell cycle regulators; IL6; IL8; NFkappaB.;

    Abstract : Fusion genes represent a growing class of translocation-derived potent oncogenes that frequently show tumor type-specific expression. We have studied the myxoid/round cell liposarcoma (MLS/RCLS)-specific FUS-DDIT3 fusion, with the aim of functionally characterizing this fusion oncogene in sarcoma development. READ MORE

  5. 3. FET proteins in cancer and development

    Author : Mattias K Andersson; Göteborgs universitet; []
    Keywords : FUS; EWS; TAF15; FUS-DDIT3; myxoid liposarcoma; NF-κB; NFKBIZ; FLT1; CDK2;

    Abstract : Chromosomal translocations leading to rearrangements of FET family genes (FUS, EWSR1 and TAF15) are found in numerous human cancers. These genetic alterations result in the formation of fusion oncogenes that express potent chimeric oncoproteins able to promote tumor development. READ MORE

  6. 4. The role of fusion oncogenes and cancer stem cells in myxoid liposarcoma

    Author : Soheila Dolatabadi; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; FUS; FUS-DDIT3; myxoid liposarcoma; cancer stem cells; JAK-STAT;

    Abstract : Myxoid liposarcoma (MLS) is characterised by the FUS-DDIT3, or the less common EWSR1-DDIT3 fusion oncogene and is the second most common type of liposarcoma. The fusion oncogenes encode chimeric transcription factors that are causal factors in tumourigenesis however, their functions are poorly known. READ MORE

  7. 5. Identification and Characterization of Novel Candidate Oncogenes

    Author : Marina Mencinger; Avdelningen för klinisk genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk genetik; Clinical genetics; RBP56; APRIL; TFG; FUS; EWS; EST database; fusion genes; chromosome; molecular genetics; cancer; Cytology; oncology; cancerology; Cytologi; onkologi;

    Abstract : Using computer-assisted sequence homology searches we identified three genes encoding proteins similar to certain fusion partner proteins in cancer. The novel APRIL gene was localized to 15q25 and encodes a protein, containing an acidic amino-acid region similar to that/those of leukemia-associated fusion partner proteins DEK and SET. READ MORE