Search for dissertations about: "FZD6"

Found 4 swedish dissertations containing the word FZD6.

  2. 1. Molecular Studies of Diamond-Blackfan Anemia and Congenital Nail Dysplasia

    Author : Anne-Sophie Fröjmark; Niklas Dahl; Catharina Larsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diamond-Blackfan Anemia; RPS19; RPS24; PIM-1; Erythropoiesis; Cell cycle; Apoptosis; Nail dysplasia; FZD6; WNT signaling; Clinical genetics; Klinisk genetik;

    Abstract : The aim of this thesis is to investigate the effect of genetic mutations on the pathophysiology of two human disorders: Diamond-Blackfan Anemia (DBA) and isolated congenital nail dysplasia. The first part of this thesis (Paper I-III) investigates the mechanism associated with DBA. READ MORE

  4. 2. Structural and functional analysis of WNT receptors : with emphasis on FZD6

    Author : Julian Petersen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Many cellular processes are dependent on the activation of G protein-coupled receptors (GPCRs). The development of drugs that can specifically target GPCRs and their corresponding signalling cascades is of high interest. READ MORE

  5. 3. Frizzled as a G protein-coupled receptor : the role of disheveled and G proteins for signal specification

    Author : Michaela Kilander; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cell communication governed and coordinated by the WNT family of lipoglycoproteins comprises essential physiological processes active throughout the life-span of metazoan organisms. In humans, severe diseases and congenital birth defects have been directly linked to disturbances in WNT signaling. READ MORE

  6. 4. Novel insights into dishevelled and frizzled function

    Author : Jana Valnohova; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The formation of a multicellular body during embryonic development is one of the most fascinating processes in biology. The cells are in constant communication and must be precisely coordinated. Several essential signalling pathways have been identified in cell-to-cell signal transmission. READ MORE