Search for dissertations about: "Factor VIII"

Showing result 16 - 20 of 49 swedish dissertations containing the words Factor VIII.

2. 16. Isolation and characterization of genes within the region for multiple endocrine neoplasia type 1 on chromosome 11q13

   Author : Jacob Lagercrantz; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Multiple Endocrine Neoplasia type 1 MEN1 ; Chromosome 11q13; Phospholipase C Beta 3 gene PLCB3 ; Phospholipase C Beta 3 Neighbouring Gene PNG ; Vascular Endothelial Growth Factor VEGF ; VEGF Related Factor gene VRF .;

   Abstract : This thesis summarizes the investigations of three genes isolated from the locus for multiple endocrine neoplasia type 1 (MEN1) within the chromosomal region 11q13. As a common strategy for all three genes, the cDNA was sequenced, the genomic structure characterized, and the expression pattern analyzed by Northern blotting on human tissues and by in situ RNA hybridization on slides from rodent embryos. READ MORE

4. 17. Reproductive aspects of the protein C system in women

   Author : Margareta Wramsby; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Hypercoagulation; Factor V Leiden; APC resistance; Protein C inhibitor; Recurrent abortions; Menstrual cycle; Pregnancy; Controlled ovarian hyperstimulation.;

   Abstract : Of great importance to the reproductive system in women are the activating and inhibiting factors which maintain haemostatic balance. These play a prominent role in the prevention of abnormal bleeding, at ovulation as well as during menstruation, pregnancy and delivery. The coagulation cascade is primarily down regulated by the protein C system. READ MORE

5. 18. Investigating a cell replacement therapy in the inner ear

   Author : Zhengqing Hu; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Adult neural stem cell; Cell therapy; Differentiation; Dorsal root ganglion; Embryonic stem cell; Gene transfer; Hearing loss; Nerve growth factor; Neurogenin; Organ of Corti; Spiral ganglion; Transplantation;

   Abstract : The mammalian auditory system is sensitive to genetic disorders, aging and injuries caused by overstimulation, ototoxic drugs and viral infections. Since the sensory epithelium (the organ of Corti) and the spiral ganglion neurons (SGNs) in adult mammalian do not regenerate spontaneously when they are damaged, a cell substitution strategy was proposed to compensate the function of the degenerated SGNs. READ MORE

6. 19. Structural studies of protein : protein complexes in the early secretory pathway

   Author : Maria Svärd; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : In this thesis, components of three different protein-protein complexes in the early secretory pathway have been studied by NMR spectroscopy and X-ray crystallography, with the aim of giving detailed structural information on each protein and gaining a deeper insight into the molecular mechanisms by which each protein performs its function and interactions. The work has resulted in the three-dimensional structures of MCFD2, a protein involved in transport of coagulation factors V and VIII, Erv41p, a vesicle protein proposed to play a role in glycoprotein processing and transport, and the co-chaperone P58IPK. READ MORE

7. 20. Hepatic and Portal Vein Thrombosis : studies on epidemiology and risk factors

   Author : Rupesh Rajani; Sven Almer; Tomas Lindahl; Dominique-Charles Valla; Linköpings universitet; []
   Keywords : MEDICINE; MEDICIN;

   Abstract : Budd-Chiari syndrome (BCS) i.e. thrombosis in the hepatic veins and/or inferior vena cava, and portal vein thrombosis (PVT) are rare disorders. Epidemiological data are scarce and previous reports have been from highly specialised referral centres. READ MORE